The Presence of Metabolic Syndrome Components in Obese Female Subjects in General Population
Keywords:
metabolic syndrome, obesity, female.
Abstract
The percentage of overweight/ obese adult female in Indonesia in 2008 was 25% and 6.9%, consecutively. Metabolic syndrome associates with increase in all-cause mortality, increase risk of some cancers in adult and postmenopausal female, diabetes melitus and cardiovascular disease in elderly. NCD deaths account for 34% of overall annual deaths in SEAR countries, and more than 55% in Indonesia. Little known about MetS and the existence of its components among obese adult females in general population. This study aims to evaluate metabolic syndrome components in obese female subjects from general population. This cross sectional study conducted in Medan-North Sumatra. The subjects had no history of hypertension, hyperlipidemia, and diabetes melitus, nor taking medication for treatment. Subjects recruited consecutively with purposive sampling. Body height, body weight, blood pressure, laboratory examination for high-density lipoprotein cholesterol levels, triglyceride levels, and fasting plasma glucose levels were measured. Subjects are 24 obese female adults, age between 30-61 year, waist circumference 92.0-43.0 cm, and body mass index ranges from 30.18-56.20 kg /m2. Study found that 18 (75.0%) subjects were with metabolic syndrome (MetS), and 6 (25.0%) subjects were not metabolic syndrome (NMetS). In MetS subjects, the component found were low HDLc levels (in 70.8%), raised TG levels (58.3%), raised FPG levels (41.7%), and increased BP (33.3%). In NMets subjects, components found were increased BP (found in 12.5%), and low HDLc levels (in 8.3%). In this study, obese female subjects experienced MetS and NMetS, the components found were decreased HDLc levels, increase in TG levels, FPG levels, and BP.References
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[2] World Health Organization. "Health and Development Challenges of Noncommunicable Disease in the South-East Asia Region Report of the Regional Meeting".[Internet]: http://apps.searo.who.int/PDS_DOCS/B4740.pdf [Mar 12, 2018]
[3] C. D. Fryar, M.D. Carroll, C.L. Ogden. "Prevalence of Overweight, Obesity, and Extreme Obesity Among Adults Aged 20 and Over: United States, 1960–1962 Through 2013–2014" [Internet] : https://www.cdc.gov/nchs/data/hestat/obesity_adult_13_14/obesity_adult_13_14.pdf [Mar 2, 2018]
[4] World Health Organization [WHO], Mendis S. "Global Status Report on noncommunicable diseases 2014". [Internet]: http://www.who.int/nmh/publications/ncd-status-report-2014/en/ [Mar 12,2018]
[5] K. Dragsbaek, J. S. Neergaard, J.M. Laursen, H. B. Hansen, C Christiansen, H Beck-Nielsen, et al. "Metabolic syndrome and subsequent risk of type 2 diabetes and cardiovascular disease in elderly women". Medicine. vol. 95, pp.1 - 8, 2016.
[6] A. Vryonidou, S. A. Paschou, G. Muscogiuri, F. Orio, D. G. Goulis. "Mechanisms in Endocrinology. Metabolic syndrome through the female life cycle". European Journal of Endocrinology. vol. 173, pp. R153 - 63, 2015.
[7] A. Al. Awlaqi, K. Alkhayat, M. E. Hammadeh. "Metabolic syndrome and infertility in women". International Journal of Women’s Health and Reproduction Science. vol. 4, pp. 89 - 95, 2016.
[8] H. M. Kim, J. Park, S. Y. Ryu, J. Kim. "The Effect of Menopause on the Metabolic Syndrome Among Korean Women The Korean National Health and Nutrition Examination Survey, 2001". Diabetes Care. vol. 30, pp 701 - 6, 2007.
[9] K. Esposito, P. Chiodini, A. Capuano, G. Bellastella, M. I. Maiorino, C. Rafaniello, et al. "Metabolic syndrome and postmenopausal breast cancer". Menopause. vol. 21, pp 1301-9, 2013.
[10] K. Esposito, P. Chiodini, A. Colao, A Lenzi, D. Giugliano. "Metabolic syndrome and risk of cancer: A systematic review and meta-analysis". Diabetes Care. vol. 35, pp 2402 - 11, 2012.
[11] R. Bhandari, G. A. Kelley, T. A. Hartley, I. R. H. Rockett. "Metabolic Syndrome Is Associated with Increased Breast Cancer Risk A Systematic Review with Meta-Analysis". International Journal of Breast Cancer. vol. 2014, pp. 1 - 13, 2014.
[12] S. Mottillo, K. B. Filion, J. Genest, L. Joseph, L. Pilote, P. Poirier, et al. "The metabolic syndrome and cardiovascular risk A systematic review and meta-analysis". Journal of the Americal College of Cardiology. vol. 56, pp. 1113- 32, 2010.
[13] G. Marchesini, E. Bugianesi, G. Forlani, F. Cerrelli, M. Lenzi, R. Manini, et al. "Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome". Hepatology. vol. 37, pp 917 - 23, 2003.
[14] N. Sattar, A. Gaw, O. Scherbakova, I. Ford, D. S. J. O’Reilly, S. M. Haffner, et al. "Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study". Circulation. vol. 108, pp. 414 - 9, 2003.
[15] J. P. Selph, W. M. Whited, A. B. Smith, J. Matthews, R. S. Pruthi, E. M. Wallen, et al. "Metabolic Syndrome as a predictor for postoperative complications after urologic surgery". Urology. vol. 83, pp.1051-9, 2014.
[16] J. Pomares, G. Mora-Garcia, R. Palomino, Y. DeLeon, C. Gómez-Alegria, D. Gómez‑Camargo. "Metabolic syndrome and perioperative complications during elective surgery using general anesthesia". Open Journal of Anesthesiology. vol. 4, pp. 167 - 76, 2014.
[17] A. I. Edelstein, F. Lovecchio, D. E. Delagrammaticas, D. W. Fitz, K. D. Hardt, D. W. Manning. "The Impact of Metabolic Syndrome on 30-Day Complications Following Total Joint" The Journal of Arthrosplasty. vol 32, pp. 362-6, 2017.
[18] R. C. Bonadonna, D. Cucinotta, D. Fedele, G. Riccardi, A. Tiengo. "The metabolic syndrome is a risk indicator of microvascular and macrovascular complications in diabetes: Results from Metascreen, a multicenter diabetes clinic-based survey". Diabetes Care. vol. 29, pp. 2701- 7, 2006.
[19] A. A. Paula, M. C.N. Falcão, A.G. Pacheco. "Metabolic syndrome in HIV-infected individuals: underlying mechanisms and epidemiological aspects". AIDS Research and Therapy. vol. 10, p. 32, 2013.
[20] International Diabetes Federation, S. G. Alberti, P. J. S. Zimmet, S. M. Grundy. "The IDF consensus worldwide definition of the metabolic syndrome [Internet].: http://www.idf.org/webdata/docs/MetS_def_update2006.pdf [Nov 23, 2015].
[21] American Diabetes Association. "Classification and Diagnosis of Diabetes". Diabetes Care. vol. 38, pp. S8–16, 2015.
[22] American Diabetes Association. "Executive summary: Standards of medical care in diabetes-2012". Diabetes Care. vol. 351, pp. S4-10, 2012.
[23] K. G. M. M. Alberti, R. H. Eckel, S. M. Grundy, P. Z. Zimmet, J. I. Cleeman, K. A. Donato, et al. "Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International ". Circulation. vol. 120, pp. 1640–5, 2009.
[24] S. Kamso. "Body mass index , total cholesterol , and ratio total to HDL cholesterol were determinants of metabolic syndrome in the Indonesian elderly". Medical Joural of Indonesia. vol. 16, pp. 195–200, 2007.
[25] U.I Khan, D. Wang, R. C. Thurston, M. Sowers, K. Sutton-Tyrrell, K. A. Matthews, et al. "Burden of subclinical cardiovascular disease in “metabolically benign” and “at-risk” overweight and obese women: The Study of Women’s Health Across the Nation [SWAN]". Atherosclerosis. vol. 217, pp. 179–86, 2011.
[26] U. I. Khan, D. Wang, C. A. Karvonen-Gutierrez, N. Khalil, K. R. Ylitalo, N. Santoro. "Progression from metabolically benign to at-risk obesity in perimenopausal women: A longitudinal analysis of Study of Women Across the Nation [SWAN]". The Journal of Clinical Endocrinology & Metabolism. vol. 99, pp. 2516–25, 2014.
[27] U. I. Khan, A. D. Ogorodnikova, L. Xu, D. Wang, S. Wassertheil-Smoller, G. Y. F. Ho, et al. "The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women: The Women’s Health Initiative Observational Study". Obesity. vol 22, pp 786 - 94, 2014.
[28] M. Hamer, E. Stamatakis. "Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality". The Journal of Clinical Endocrinology & Metabolism. vol. 97, pp. 2482–8, 2012.
[29] P. K. Whelton, R. M. Carey, W. S. Aronow, D. E. Casey, K. J. Collins, C. Dennison Himmelfarb, et al. "2017 ACC/ AHA/ AAPA/ ABC/ ACPM/ AGS/ APhA/ ASH/ ASPC/ NMA/ PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines". Hypertension. vol.0, pp.0-0, 2017.
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2018-03-20
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