The Relationship between Ultraviolet, Vitamin D and Blood Glucose, in Vivo Study
This study is carried on to investigate the effect of (UV) on the estimate of vitamin D production and the correlation ratio of vitamin D and its impact on the increase of blood glucose finally to prove the relationship via biochemical analysis of Vitamin D and glucose level. 90 adult rats were randomly divided into three groups. G1 (-ve control): This group contains 30 rats that were not exposed to the ultraviolet. Rats were eating daily/4 months. G2 (+ve control): This group contains 30 rats that were not exposed to the ultraviolet. Rats were fasting 2 days and eat the third day frequently (4 months). G3: Test group: To examine the exposed to the ultraviolet for 10 second to simulate sunrise and another 10 second to simulate sunset (using prototype cage). This group contains 30 rats, which were fasting 2 days and eat the third day frequently (4 months). Weights were recorder every week. The blood samples were collected through retro- orbital venous plexus in the zero time, every month, and at the end of four months and the obtained sera were subjected to the Glucose and D3 tests. The results showed that the body weights were reducing significantly in G1 compared with G3 at all measured periods (P < 0.000). Whereas no significant differences between G3 and G2 in all weeks. The Glucose levels in G1 and G3 were raised significantly in (1st, 2nd, 3rd and 4th month) (P< 0 .035), (P< 0 .036), (P< 0.030) and (P< 0.023). Also blood level of Glucose was raised significantly between G3 and G2 in all periods (P< 0 .008), (P< 0 .009), (P< 0.002) and (P< 0.001). Moreover the blood levels of Vitamin D between G1 and G3 were raised significantly in all tested periods (P< 0 .001), (P< 0 .000), (P< 0.000) and (P< 0.003). Also Vitamin D was raised significant (P< 0.000) in G3 compared with G2. This study was proved that vitamin D level was affected by the exposure to ultraviolet that intern affect the glucose level. Also ultraviolet (UV) extend to preservation of glucose homeostasis by raising glucose level. Accordingly ultraviolet (UV) raising vitamin D should be considered since this may help reduce the risk of glucose disorders.
SEMINARIO, A. L. & VELAN, E. 2016. Vitamin D and Dental Caries in Primary Dentition. Journal of Dentistry for Children, 83, 114-119.
OH, T. J., LIM, S., KIM, K. M., MOON, J. H., CHOI, S. H., CHO, Y. M., PARK, K. S., JANG, H. & CHO, N. H. 2017. One‐hour postload plasma glucose concentration in people with normal glucose homeostasis predicts future diabetes mellitus: a 12‐year community‐based cohort study. Clinical Endocrinology, 86, 513-519.
KIM, G.-Y., LEE, Y. M., KWON, J. H., CHO, J.-H., PAN, C.-J., STAROST, M. F., MANSFIELD, B. C. & CHOU, J. Y. 2017. Glycogen storage disease type Ia mice with< 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors. Molecular Genetics and Metabolism.
HOLICK, M. F. 2007. Vitamin D deficiency. New England Journal of Medicine, 357, 266-281.
WHITAKER, R. J. 2003. Color and Light in Nature. School Science and Mathematics, 103, 354-355.
DASH, K., VENKATESWARLU, G., THANGAVEL, S., RAO, S. & CHAURASIA, S. 2011. Ultraviolet photolysis assisted mineralization and determination of trace levels of Cr, Cd, Cu, Sn, and Pb in isosulfan blue by ICP-MS. Microchemical Journal, 98, 312-316.
CHRISTAKOS, S., DHAWAN, P., VERSTUYF, A., VERLINDEN, L. & CARMELIET, G. 2016. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological reviews, 96, 365-408.
JELINEK, G. A., MARCK, C. H., WEILAND, T. J., PEREIRA, N., VAN DER MEER, D. M. & HADGKISS, E. J. 2015. Latitude, sun exposure and vitamin D supplementation: associations with quality of life and disease outcomes in a large international cohort of people with multiple sclerosis. BMC neurology, 15, 132.
KRAUSE, R., STANGE, R., KAASE, H. & HOLICK, M. F. 2016. UV irradiation and pleiotropic effects of vitamin D in chronic kidney disease–Benefits on cardiovascular comorbidities and quality of life. Anticancer research, 36, 1403-1408.
OSMANCEVIC, A., GILLSTEDT, M., LANDIN-WILHELMSEN, K., LARKö, A.-M. W., LARKö, O., HOLICK, M. F. & KROGSTAD, A.-L. 2015. Size of the exposed body surface area, skin erythema and body mass index predict skin production of vitamin D. Journal of Photochemistry and Photobiology B: Biology, 149, 224-229.
MCCARROLL, K., BEIRNE, A., CASEY, M., MCNULTY, H., WARD, M., HOEY, L., MOLLOY, A., LAIRD, E., HEALY, M. & STRAIN, J. 2015. Determinants of 25-hydroxyvitamin D in older Irish adults. Age and ageing, afv090.
YOSHIDA, T., OKUNO, A., TAKAHASHI, K., OGAWA, J., HAGISAWA, Y., KANDA, S. & FUJIWARA, T. 2011. Contributions of hepatic gluconeogenesis suppression and compensative glycogenolysis on the glucose-lowering effect of CS-917, a fructose 1, 6-bisphosphatase inhibitor, in non-obese type 2 diabetes Goto-Kakizaki rats. Journal of pharmacological sciences, 115, 329-335.
JACOBI, D., CHO, H. J., ALEXANDER, R. K. & LEE, C.-H. 2016. Metabolic Rhythm of Hepatic Lipogenesis: Regulation and Roles in Metabolism. Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer.
BECHMANN, L. P., HANNIVOORT, R. A., GERKEN, G., HOTAMISLIGIL, G. S., TRAUNER, M. & CANBAY, A. 2012. The interaction of hepatic lipid and glucose metabolism in liver diseases. Journal of hepatology, 56, 952-964.
MAIORANA, A., MANGANOZZI, L., BARBETTI, F., BERNABEI, S., GALLO, G., CUSMAI, R., CAVIGLIA, S. & DIONISI-VICI, C. 2015. Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage. Orphanet journal of rare diseases, 10, 120.
* Asma Bukhari. “The Relationship between Ultraviolet, Vitamin D and Blood Glucose, In Vivo Study.” Saudi Arabia. Patent, May. 3, 2017.
A. Bukhari. Dr.firstname.lastname@example.org: (May. 3, 2017).
- There are currently no refbacks.