Efficacy of Apitherapy for Skin Regeneration
AbstractIn daily routine, skin may be exposed to diverse severity showing wounds and burns which heal at different rate. This variation in dermal recovery and regeneration rate indirectly indicates the physiological factors which function to reestablish internal normal state of the body. To speed up the process of skin healing, several cost effective local produce based boosters are utilized for treatment of dermal burns and injuries. In this regard, honey bee products are preferred as alternative than side effects inducing anthropogenic medicines. Apitherapy (bee therapy) is the broad-spectrum pharmaceutical appliance of honey, propolis, bee pollen, royal jelly, bee wax, bee venom and bee bread which are commonly obtained products from honey bees and are considered as ideal skin healers due to their suitable biochemical composition, antimicrobial, anti-inflammatory and other supportive qualities. Thus, further research efforts are required for better apiculture techniques and dose optimization of these bee products to replace many hazardous antibiotics and other synthetic drugs.
. Javed, A. and J.I. Qazi, 2016. Efficacy of Azadirachta indica and Solanum nigrum for Skin Regeneration in Mice. Pak. J. Life Soc. Sci., 14: 158-166.
. Wang, J.M.W., 2017. Functional electrospun fibers for the treatment of human skin wounds. European Journal of Pharmaceutics and Biopharmaceutics, 119: 283-299.
. Javed, A., M. Usman, S.M. Haider, B. Zafar, K. Iftikhar and U.I. Haq, 2019. Potential of indigenous plants for skin healing and care. ASRJETS. 50: 192-211.
. Chan, E.W.C., Y.Y. Lim, L.F. Wong, F.S. Lianto, S.K. Wong, K.K. Lim, C.E. Joe and T.Y. Lim, 2008. Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species. Food Chem., 109: 477-483.
. Paonta, S. and G. Divya, 2016. Ayurvedic remedies for healing of wounds: a review. Int. J. Pharm. Med. Res., 4: 342-349.
. Garraud, O., W.N. Hozzein, and G. Badr, 2017. Wound healing: time to look for intelligent, ‘natural’ immunological approaches? BMC Immunol., 18: 23.
. Jalil, M.A.A., A.R. Kasmuri and H. Hazrina, 2017. Stingless bee honey, the natural wound healer: a review. Skin Pharmacol. Physiol., 30: 66–75.
. Minden-Birkenmaier, B. A. and G. L. Bowlin, 2018. Honey-Based Templates in Wound Healing and Tissue Engineering. Bioengineering 2018, 46(5):1-27.
. Menke, N.B., K.R. Ward, T.M. Witten, D.G. Bonchev and R.F. Diegelmann, 2007. Impaired wound healing. Clin. Dermatol., 25: 19-25.
. Krishnan, P., 2006. The scientific study of herbal wound healing therapies: Current state of play. Curr. Anaesthesia Crit. Care, 17:21-27.
. Worden, A.Y., J.H. Daniel, M. Herman, H. Kenneth, S. Iltefat and S. I. Aamir, 2020. Factors affecting healing in the treatment of hidradenitis suppurativa. Annals of Plastic Surgery, 84: 436-440.
. Kerstein, M.D., 2007. Factors affecting wound healing. Adv. wound care, 10: 30-36.
. Colligan, E., A. Metzler and E. Tiryaki, 2017. Shared decision-making in multiple sclerosis. Multiple Sclerosis Journal, 23(2): 185–190.
. Fratellone, P.M., F. Tsimis and G. Fratellone, 2016. Apitherapy products for medicinal use. J. Altern. Complement Med., 22: 1020–1022.
. Hellner, M., D. Winter, R.V. Georgi, and T.K. Munsted, 2008. Apitherapy: usage and experience in German bee keepers. eCAM, 5: 475-79.
. Majtán, J., 2009. Apitherapy: The role of honey in the chronic wound healing process. Epidemiol. Microbiol. Imunol., 58: 137–140.
. Górecka, K.A., M. Górecki, A. Rzepecka-Stojko, R. Balwierz, and J. Stojko, 2020. Bee Products in Dermatology and Skin Care. Molecules, 25: 556.
. Barbosa, N.S. and A.N. Kalaaji, 2014. CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C? Complement Ther. Clin. Pract., 20: 11-5.
. Oryan, A., E. Alemzadeh and A. Moshiri, 2016. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. J. Tissue Viability, 25: 98-118.
. The Holy Quran, section: 16, verses: 68–69.
. De Almeida, E.B., C.J. Cordeiro, A.K. De Lima, N.L. De Oliveira, N.T. De Pontes-Filho, L.S. Oliveira, I.C. Souza, and R.L. De Albuquerque-Júnior, 2013. The incorporation of Brazilian propolis into collagen based dressing films improves dermal burn healing. J. Ethnopharmacol., 147: 419–425.
. Hozzein, W.N., G. Badr, A.A. Al Ghamdi, A. Sayed, N.S. Al-Waili and O. Garraud, 2015. Topical application of propolis enhances cutaneous wound healing by promoting TGF-beta/Smad-mediated collagen production in a streptozotocin-induced type I diabetic mouse model. Cell Physiol. Biochem., 37: 940–954.
. Izuta, H., M. Shimazawa, K. Tsuruma, Y. Araki, S. Mishima and H. Hara, 2009. Bee products prevent VEGF induced angiogenesis in human umbilical vein endothelial cells. BMC Complementary and Alternative Medicine, 45:1-10.
. Jacob. A., A. Parolia, A. Pau and F.D. Amalraj, 2015. The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process. BMC Complement Altern. Med., 15: 294.
. De Rezende, G.P.S.R., L.R.R.S. Da Costa, F.C. Pimenta and D.A. Baroni, 2008. In vitro antimicrobial activity of endodontic pastes with propolis extracts and calcium hydroxide. Braz. Dent. J., 19: 301-5.
. Olczyk, P., R. Koprowski, J. Kaźmierczak, L. Mencner, R. Wojtyczka, J. Stojko, K. Olczyk and V.K. Komosinska, 2016. Bee pollen as a promising agent in the burn wounds treatment. Evid. Based Complement Alternat. Med., 2016: 1-12.
. Takzaree, N., A. Hadjiakhondi, G. Hassanzadeh, M.R. Rouini and A. Manayi, 2016. Synergistic effect of honey and propolis on cutaneous wound healing in rats. Acta Med. Iranica., 54: 233–239.
. Baltrušaitytė, V., P.R. Venskutonis and V. Čeksterytė, 2007. Antibacterial activity of honey and beebread of different origin against S. aureus and S. epidermidis. Food Technol. Biotechnol., 45: 201–208.
. Choi, E.M., 2007. Antinociceptive and anti-inflammatory activities of pine (Pinus densiflora) pollen extract. Phytother. Res., 21: 471–475.
. Han, S.M., J.M. Kim, I.P. Hong, S.O. Woo, S.G. Kim, H.R. Jang and S.C. Pak, 2016. Antibacterial activity and antibiotic-enhancing effects of honeybee venom against methicillin-resistant Staphylococcus aureus. Molecules, 21: 79.
. Khan, S., Q.H. Lari, and M.A. Khan, 2016. Therapeutic uses of Mom Zard (bees wax) in Unani system of medicine-a review. Int. J. Pharm. Bio-Sci., 1: 1–4.
. Fu, H., X.J. Wang, H.F. Lu and Q.W. Xu, 2007. Experimental study on beeswax ointment in diabetic rabbit's model of wound healing. J. Dalian Med. Univ., 4: 003.
. Amin, M.A. and I.T. Abdel-Raheem, 2014. Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol–chitosan hydrogel containing honey bee venom in diabetic rats. Arch Pharm Res., 37: 1016–1031.
. Badr, G., W.N. Hozzein, B.M. Badr, A. Al Ghamdi, E.H.M. Saad and Garraud, O., 2016. Bee venom accelerates wound healing in diabetic mice by suppressing activating transcription factor-3 (ATF-3) and inducible nitric oxide synthase (iNOS)-mediated oxidative stress and recruiting bone marrow derived endothelial progenitor cells. J. Cell Physiol., 231: 2159–2171.
. Gajski, G., T. Čimbora-Zovko, S. Rak, M. Rožman, M. Osmak and V. Garaj-Vrhovac, 2014. Combined antitumor effects of bee venom and cisplatin on human cervical and laryngeal carcinoma cells and their drug resistant sublines. J. Appl. Toxicol., 34: 1332–1341.
. Han, S.M., K.K. Park, Y.M. Nicholls, N. Macfarlane and G. Duncan, 2013. Effects of honeybee (Apis mellifera) venom on keratinocyte migration in vitro. Pharmacology Mag, 9: 220–226.
. Kocyigit, A., E.M. Guler, and S. Kaleli, 2016. Anti-inflammatory, antioxidant and anti-genotoxic effects potential mechanisms and application of honeybee products in wound management of different doses of bee venom on adjuvant induce arthritis in rats. J. Int. Soc. Antioxidants Nutr. Health, 3: 1-6.
. Vasileiadou, K., G. Pantazidis, K. Papadopoulou, C. Ligoudistianou, A. Kourelis, S. Petrakis, E. Masmanidou, T. Testa, A. Kourounakis and L., Hadjipetrou, 2010. α1-Acid glycoprotein production in rat dorsal air pouch in response to inflammatory stimuli, dexamethasone and honey bee venom. Exp. Mol. Pathol., 89: 63–71.
. Khalifa, S.A.M., E. Mohamed, K. Marek, E.G. Naglaa, A.F. Mohamed, S. Aamer, X. Jianbo, Z. Xiaobo, K. Alfi, G. Ulf and H. R. El-Seedi. 2020. Recent insights into chemical and pharmacological studies of bee bread. Trend in Food Science and Technology, 97: 300-316.
. Kieliszek, M., P. Kamil, M.K. Anna, B. Stanislaw, C.S. Anna and W. Wona, 2018. Pollen and bee bread as new health oriented products. Trend in Food Science and Technology, 71: 170-180.
. Kurek, A. G., G Michał, S. A. Rzepecka, B. Radosław, and S. Jerzy, 2020. Review Bee Products in Dermatology and Skin Care. Molecules, 556: 1-17.
. Çağr, T., C.H. Mustafa, B.Y. Murat, C. Ali, E. Osman, T.T. Hamdi, Y. Abdullah and G. Murat 2017. Factors affecting mortality among victims of electrical burns. Ulus Travma Acil Cerrahi Derg., 23: 223–229.
. Marek, K., P. Kamil, M. Anna, S.B. Kot, Ś. A. Chlebowska, and W. Iwona, 2018. Pollen and bee bread as new health-oriented products: A review. Trends in Food Science & Technology, 71: 170–180.
. Shaden, A.M., M.E. Khalifa, K. Marek, E.G. Naglaa, A. Mohamed, A.S. Farag, X. Jianbo, Z. Xiaobo, K. Alfi, U.l.f. Göransson, R.H. El-Seedi, 2020. Recent insights into chemical and pharmacological studies of bee bread. Trends in Food Science & Technology, 97: 300–316.
. Young, H.K., M.C. Hong, G.K. Se, O.W. Soon, J.M. Hyo and M.H. Sang, 2020. Skin health improving effects of Korean freeze-dried royal jelly in human keratinocytes. Asian J. Beauty Cosmeto., 18: 413-422.
. Javed, A., M. Usman, N. Akram, S. Kanwal, I. Riaz, and S.M. Haider, 2019. Nigella sativa a potent healer for diabetic wounds and its other pharamcognosal attributes. Haya Saudi J Life Sci., 4(4): 173-179.
Copyright (c) 2021 American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who submit papers with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- By submitting the processing fee, it is understood that the author has agreed to our terms and conditions which may change from time to time without any notice.
- It should be clear for authors that the Editor In Chief is responsible for the final decision about the submitted papers; have the right to accept\reject any paper. The Editor In Chief will choose any option from the following to review the submitted papers:A. send the paper to two reviewers, if the results were negative by one reviewer and positive by the other one; then the editor may send the paper for third reviewer or he take immediately the final decision by accepting\rejecting the paper. The Editor In Chief will ask the selected reviewers to present the results within 7 working days, if they were unable to complete the review within the agreed period then the editor have the right to resend the papers for new reviewers using the same procedure. If the Editor In Chief was not able to find suitable reviewers for certain papers then he have the right to accept\reject the paper.B. sends the paper to a selected editorial board member(s). C. the Editor In Chief himself evaluates the paper.
- Author will take the responsibility what so ever if any copyright infringement or any other violation of any law is done by publishing the research work by the author
- Before publishing, author must check whether this journal is accepted by his employer, or any authority he intends to submit his research work. we will not be responsible in this matter.
- If at any time, due to any legal reason, if the journal stops accepting manuscripts or could not publish already accepted manuscripts, we will have the right to cancel all or any one of the manuscripts without any compensation or returning back any kind of processing cost.
- The cost covered in the publication fees is only for online publication of a single manuscript.