Camel Milk as Adjuvant to Treat Alloxan Diabetes: Effect of Heat Treatment on this Property
Keywords:
Diabetes, Alloxan, Pasteurized, HyperglycemiaAbstract
Diabetes is one of the most frequent and serious chronic diseases in humans all over the world. The aim of our study was to evaluate the effect of heat treatment on antidiabetic activity of camel milk on serum glucose and lipid profile of alloxan-induced diabetic rats. Diabetes was induced in Wistar albino rats by intraperitoneal injection of alloxan (120 mg/kg BW once). Albino rats each weighing 180-230g were divided into 3 equal groups (n=4) as following: G1- normal rats fed on normal diet, G2 - diabetic rats fed on normal diet, and G3 - diabetic rats were fed with raw camel milk. Fasting blood glucose was measured lipid profile was assessed. Results: Our study showed a significant effect of raw camel milk on blood glucose and lipid profile parameters in alloxan induced diabetic rats, there was a significant reduction in lipid profile of T. Cholesterol, Triglycerides, LDL-C in (Diabetic+ Raw camel milk) comparing to (Diabetic+ Pasteurized camel milk) and Positive control group with values 121.4 mg/dl, 80.4 mg/dl, 17.9 mg/dl and 141.5 mg/dl, 90.7 mg/dl, 28.7 mg/dl and 181.6 mg/dl, 113.8 mg/dl, 48.9 mg/dl respectively. Diabetic+ Boiled camel milk group died at the end of experiment. Conclusion: Raw camel milk improved the glycemic and lipid profile in diabetic rats but not in Diabetic+ Boiled camel milk group. These findings indicate that boiling of raw camel milk may have reducing potential benefits in the treatment of diabetes. Future studies will be needed to establish its safety and mechanism of action.
References
Ozougwu J.C., Obimba K.C., Belonwu C.D., Unakalamba C.B. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. Journal of Physiology and Pathophysiology, 2013, 4: 46-57.
American Diabetes Association (ADA). Diagnosis and classification of diabetes Mellitus. Diabetes Care 36(Suppl 1), 2013: S67–S74.
Shaaban M., Dawod A.E., Nasr M.A. Role of iron in diabetes mellitus and its complications. Menoufia Medical Journal, 2016, 29: 11-16.
Murti K., Kaushik M., Kaushik A. Evaluation of hyypoglycemic and hypolipidemic activity of nyctanthes arbortristis linn against streptozotocin induced diabetic rats. American Journal of Pharmacology and Toxicology, 2012, 7: 8–11.
Obeten K.E., Ubom K.S., Charles C.M. Some histological changes in the intestines of alloxan induced diabetic mellitus albino rats. Journal of Biology, Agriculture and Healthcare, 2014, 4: 81-84.
Rodrigues R. A comprehensive review: The use of animal models in diabetes research. J Anal Pharm Res, 2016, 3(5): 00071.
Yadav A.K., Kumar R., Priyadarshini L., Singh J. Composition and medicinal properties of camel milk: A review. Asian J Dairy & Food Res, 2015, 34: 83-91.
Manal M.E.M. Shehata, Eman A.M. Evaluation of therapeutic efficiency of camel milk on alloxan-induced diabetic rats. Journal of American Science, 2014, 10: 53-60.
Agrawal R.P., Saran S., Sharma P., Gupta R.P., Kochar D.K., Sahani M.S. Effect of camel milk on residual β-cell function in recent onset type 1 diabetes. Diabetes Res Clin Pract, 2007, 77: 494–495.
Abd El-Aziz A.D., Ali K.A., Ahmed A.H., Mansour H.Z., Mohamed M.S. A Study on the effect of female camel (Camelus Dromedarius) milk on glycemic control of streptozotocin (STZ) induced diabetes mellitus in rats. Journal of American Science, 2012, 8: 459-465.
Badr G., Bashandy S., Ebaid H., Mohany M., Sayed D. Vitamin C supplementation reconstitutes polyfunctional T cells in streptozotocin-induced diabetic rats. Eur J Nutr, 2012, 51: 623–633.
Downloads
Published
How to Cite
Issue
Section
License
Authors who submit papers with this journal agree to the following terms.