Protective Effect of Curcuma zedoria Against Copper in Rats’ White Blood Cell
AbstractCopper, an essential trace element, is essential for the human body to maintain homeostatic balance. Higher levels of copper in the human body can cause damage to the liver, kidney, and brain due to increased generation of ROS (reactive oxygen species). As an alternative solution, natural resources which can be used to reduce the impact of copper excess is Curcuma zedoria due to the presence of curcumin. This study was aimed to explore the protective effect of Curcuma zedoria against copper in rats using the WBC as an indicator. This study was performed using 15 rats that were divided into 5 groups consisting of a negative group, a positive group, and three experimental groups which were given ethanol extract of Curcuma zedoria in various dosage. Each group of rats was fed 0.36 mg/kg b.w of CuSO4 solution on the 10th to 14th day of the experiment. The results showed that the level of band neutrophil, lymphocyte, and monocyte increased following the reduction of the dosage of Curcuma Zedoria that given to the rats. However, the levels of monocyte in each group were within normal range except the negative group. Based on the higher levels of WBC, all of the experiment groups suffered chronic active inflammation. Curcuma zedoria had a protective effect against overexposure to copper in rats, but it didn’t completely protect the rats from the effects of overexposure.
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