The Effect of Antishemin on Some Respiratory Tissue Enzymes in Cerebral Ischemia Model

  • Ariuntsetseg Bat-Erdene New Medicine Medical University, Ulan Bator, Mongolia
  • Ambaga Miegombo New Medicine Medical University, Ulan Bator, Mongolia
  • Sarantsetseg Bandi New Medicine Medical University, Ulan Bator, Mongolia
  • Tserendagva Dalkh Medical National University of Science, Ulan Bator, Mongolia
Keywords: Cerebral ischemia, lactate dehydrogenase, succinate dehydrogenase, “The membrane-redox potentials three-state line system dependent-full 9 stepped cycle of proton conductance”.


Today, biology, biochemistry, and molecular biological sciences are highly developed that glycolysis, Kreb’s cycle, pentose monophosphate path have discoverd and  to study all diseases, mainly biochemistry of ischemic heart disease “The membrane-redox potentials three-state line system dependent-full 9 stepped cycle of proton conductance” by M.Ambaga is necessary to learn. Conclusion: Lactate dehydrogenase (LDH ng / L) was increased by 39.8% -66.9% in brain tissue homogeneity, which is dominated by oxygen-rich oxidation or anaerobic oxidation, and brain energy may be possible to use the glycolysis line to full the deficit. In contrast, the levels of lactate dehydrogenase were decreased by 14.5-33.9% compared to the control group with Antischemin group100 mg / kg dose, and when brain is lack of oxygen, ATP is increased by endogenic antioxidant is elevation to supply the energy. The control group that did not use succinate dehydrogenase enzyme in the cerebral homogenate was reduced to 23.8% -39.75% compared to the healthy group in cerebral ischemia, which inhibited the loss of electrons and protons in the cellular respiratory chain, it seems to be lacking. On the basis of the 100mg / kg dosage of Antischemin, the activity of the cyclic dehydrogenase activity increased by 10.23% -22.5% in theday 1-21 of the cerebral ischemia. The biologically active ingredient in the naturally occurring extracts Astragalus membranaceus, Scutellaria baicalensis georgi, and Ginkgo biloba, the compounds are strongly antioxidant, with this action preventing electrons and proton transmit in mitochondrial membranes during acute and chronic deficiency of cerebral ischemic oxygen, thereby energizing the organs and the improvement of the supply.


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