The Effect of Antishemin on Some Respiratory Tissue Enzymes in Cerebral Ischemia Model

  • Ariuntsetseg Bat-Erdene New Medicine Medical University, Ulan Bator, Mongolia
  • Ambaga Miegombo New Medicine Medical University, Ulan Bator, Mongolia
  • Sarantsetseg Bandi New Medicine Medical University, Ulan Bator, Mongolia
  • Tserendagva Dalkh Medical National University of Science, Ulan Bator, Mongolia
Keywords: Cerebral ischemia, lactate dehydrogenase, succinate dehydrogenase, “The membrane-redox potentials three-state line system dependent-full 9 stepped cycle of proton conductance”.

Abstract

Today, biology, biochemistry, and molecular biological sciences are highly developed that glycolysis, Kreb’s cycle, pentose monophosphate path have discoverd and  to study all diseases, mainly biochemistry of ischemic heart disease “The membrane-redox potentials three-state line system dependent-full 9 stepped cycle of proton conductance” by M.Ambaga is necessary to learn. Conclusion: Lactate dehydrogenase (LDH ng / L) was increased by 39.8% -66.9% in brain tissue homogeneity, which is dominated by oxygen-rich oxidation or anaerobic oxidation, and brain energy may be possible to use the glycolysis line to full the deficit. In contrast, the levels of lactate dehydrogenase were decreased by 14.5-33.9% compared to the control group with Antischemin group100 mg / kg dose, and when brain is lack of oxygen, ATP is increased by endogenic antioxidant is elevation to supply the energy. The control group that did not use succinate dehydrogenase enzyme in the cerebral homogenate was reduced to 23.8% -39.75% compared to the healthy group in cerebral ischemia, which inhibited the loss of electrons and protons in the cellular respiratory chain, it seems to be lacking. On the basis of the 100mg / kg dosage of Antischemin, the activity of the cyclic dehydrogenase activity increased by 10.23% -22.5% in theday 1-21 of the cerebral ischemia. The biologically active ingredient in the naturally occurring extracts Astragalus membranaceus, Scutellaria baicalensis georgi, and Ginkgo biloba, the compounds are strongly antioxidant, with this action preventing electrons and proton transmit in mitochondrial membranes during acute and chronic deficiency of cerebral ischemic oxygen, thereby energizing the organs and the improvement of the supply.

References

. M.Ambaga, A.Tumen-Ulzii. The three main lines of membrane-redox potential within the living cells are enclosed circuits of 9-wire proton and electrostatic flux" the value of science and cognitive significance. UB. 2018.

. M.Ambaga, A.Tumen-Ulzii. “The boundary of the three protruding membrane-redox potential in human and animal bodies is a closed circuit of nine protruding protons and electrons”. The importance of science and cognition of new theories. UB. 2019.

. Scherbak Natalia Sergeevna. “Effects and mechanisms of ischemic preconditioning and post-conditioning of the brain”. Thesis for the degree of Doctor of Biological Sciences, Sankt Petersburg, 2016. 9-11.

. M.Ambaga. “The membrane-redox potentials three-state line system dependent-full 9 stepped cycle of proton conductance as the universal metabolic formula and the development of all medical thinking during last 3000 years” Asian Journal of Science and technology, vol.08, Issue, 03, pp. 4485-4488, March.

. M.Ambaga, A.Tumen-Ulzii. NCM medicine. UB, 2018, 24-25

. M.Ambaga, A.Tumen-Ulzii. Integration of Tibetan traditional and modern medicine using NCM knowledge. 2018, 10-12

. D.Enebish. Biochemical metabolism. UB. 2015.

. D. Purev, N.Tsevegsuren. Biochemistry. UB. 2006.

. D.Enebish, E.Enkhbat, CH.Ganchimeg. General enzymological basis. UB. 2005.

. YP.Luo, H.Zhang, HF.Hu, ZY.Cao, XZ.Zhang, L.Cao, ZZ.Wang, W.Xiao. “Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats”. ZhongguoZhong Yao ZaZhi. 2017 Dec;42(24):4733-4737. doi: 10.19540/j.cnki.cjcmm.2017.0209.

. Y.Tang, G.Zhou, L.Yao, P.Xue, D.Yu, R.Xu, W.Shi, X.Yao, Z.Yan, JA.Duan. “Protective effect of Ginkgo biloba leaves extract, EGb761, on myocardium injury in ischemia reperfusion rats via regulation of TLR-4/NF-κ B signaling pathway”. Oncotarget. 2017 Sep 28;8 (49):86671-86680. doi: 10.18632/ oncotarget. 21372. E Collection 2017 Oct 17.

. L.Xu, Z.Hu, J.Shen. “Effects of Ginkgo biloba extract on cerebral oxygen and glucose metabolism in elderly patients with pre-existing cerebral ischemia”. Complement Ther Med. 2015 Apr;23(2):220-5. doi: 10.1016/j.ctim.2014.12.009. E pub 2015 Jan 5.

. L.Yan,QH.Zhou. “Study on neuroprotective effects of astragalan in rats with ischemic brain injury and its mechanisms”. 2012 Jul; 28(4):373-7

Published
2019-07-24
Section
Articles