A Comparative Study of Peel and Seed Extract of Passion Fruit (Passiflora edulis) as Antihyaluronidase

  • Darwis Darwis Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • I Nyoman Ehrich Lister Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
  • Edy Fachrial Laboratory of Molecular Biology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
Keywords: antioxidant, anti hyaluronidase, P.edulis, anti-aging, passion fruit.


The plant produces various metabolites and one among the benefit is to inhibit the aging process. The aim of the study was to compare the antioxidant activity between the peel and the seeds of P.edulis and also to compare anti-hyaluronidase activity. The antioxidant activity was determined using the ABTS reduction method. The result showed that the reduction percentage of ABTS  of seed and peel of P.edulis was 15,58 ± 1,04 % and 27,68± 0,09 % respectively at concentration 50 µg/ml. The inhibition activity of hyaluronidase of seed and peel of P.edulis was 70,96 ± 3,55 %  and 61,68 ±4,05 %. The IC50 of anti hyaluronidase activity of seed dan peel extract was 122,70 ± 6,35 and 67,35 ±6,58 respectively.  From the result, it can be concluded that the seeds and peel of P.edulis have the potential as a source of anti-aging particularly as anti hyaluronidase.


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