Antioxidant and Anticollagenase Activity of Tomato (Solanum lycopersicum L.) and Lycopene

  • Kristina Kristina Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
  • Alhoi Hendry Henderson Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
  • Djohan Djohan Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
  • I Nyoman Ehrich Lister Department of Physiology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
  • Ermi Girsang Faculty of Public Health, Universitas Prima Indonesia, Medan, Indonesia
  • Edy Fachrial Laboratory of Biomolecular, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
Keywords: Solanum lycopersicum L., Antiaging, Collagenase, Antioxidant.


Antioxidants were any substance that can inhibit oxidation that causes collagen disintegration, lipid breakdown, DNA damage and protein unfolding in the aging process. The ingredients in the cosmetics has a toxin effect in human body. To investigate the bioactive compound, an antioxidant and antiaging activity particularly as collagenase inhibitor of the tomatoes. This study used phytochemical screening for the bioactive compounds, DPPH scavenging activity for antioxidant assay and collagenase inhibition activity for the antiaging property.  The phytochemical screening shows that the Solanum lycopersicum L. extract (SLE) has flavonoid, phenol, saponin, tannin and alkaloid. The lycopene (79.45 ± 1.01) has an antioxidant activity better than SLE (147.20 ± 16.97) from DPPH scavenging activity. Lycopene (85,09 ± 1,81 μg/mL) also has the higher antiaging activity than SLE (236,74 ± 9,74 μg/mL) particularly as collagenase inhibitor. In conclusion flavonoid was the most common in the SLE. SLE has a higher antioxidant activity through DPPH scavenging activity and antiaging activity particularly as a collagenase inhibitor.


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