The Synchronous Occurrence of Neuroendocrine Tumor and Gastrointestinal Stromal Tumor (GIST) at Gastric Site

Yassine Dkhissi, Mohamed Alila, Omar marghich, Loubna Hejjane, Elbachir Benjelloun


Gastrointestinal stromal tumors (GIST) are the most frequent sarcomas in the gastrointestinal tract. They affect all segments of the digestive tract. The incidental occurrence of GIST and other primary tumors has not been well described in literature. We describe a case of a 73 year old patient who underwent surgery for gastric GIST with an incidental pathologic diagnosis of a gastric neuroendocrine tumor. The occasional finding of this association underlines the importance of a carefully pathological diagnosis for its identification. In literature there is no evidence of concomitant neuroendocrine tumor and gastrointestinal stromal tumor (GIST) at gastric site.


Gastrointestinal stromal tumor ; neuroendocrine tumor; synchronous Tumors; gastric.

Full Text:



. Blay JY, Landi B, Bonvalot S et al. Recommendations for the management of GIST patients. Bull Cancer 2005;92(10):907-18

. Miettinen M, Lasota J. Gastrointestinal stromal tumors: definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001; 438: 1-12.

. Davis GB, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Foster RS Jr et al. Tumors of the stomach. World J Surg 2000; 24: 412-20.

. Blay JY, Bonvalot S, Casali P, Choi H, Debiec-Richter M, Dei Tos AP, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20—21 March 2004, under the auspices of ESMO. Ann Oncol 2005;16:566—78.

. Ouzzif A, Seddik H, Boulez J, Scoazec JY, Lapalus MG. Digestive protein loss from an ileal multifocal stromal tumor. Gastroenterol Clin Biol 2005;29:1066—8.

. Maiorana A, Fante R, Maria CA, Adriana FR. Synchronous occurrence of epithelial and stromal tumors in the stomach: a report of 6 cases. Arch Patho Lab Med 2000;124:682e6.

. Kawanowa K, Sakuma Y, Sakurai S, Hishima T, Iwasaki Y, Saito K, et al. High incidence of microscopic gastrointestinal stromal tumors in the stomach. Hum Pathol 2006;37:1527e35.

. Igwilo OC, Byrne MP, Nguyen KD, Atkinson J. Malignant gastric stromal tumor: unusual metastatic patterns. South Med J 2003;96:512e5.

. Agaimy A, Wunsch PH, Sobin LH, Lasota J, Miettinen M. Occurrence of other malignancies in patients with gastrointestinal stromal tumors. Semin Diagn Pathol 2006;23:120e9.

. Invernizzi R, Martinelli B, Pinotti G. Association of GIST, breast cancer and schwannoma in a 60-year-old woman affected by type-1 von Recklinghausen’s neurofibromatosis. Tumori 2008;94:126e8.

. Gottwald L, Gora E, Korczynski J, Piekarski JH, Morawiec Z, JesionekKupnicka D, et al. Primary uterine rhabdomyosarcoma in a patient with a history of breast cancer and gastrointestinal stromal tumor. J Obstet Gynaecol Res 2008;34:721e5.

. Nakamura S, Aoyagi K, Iwanaga S, et al. Synchronous and metachronous primary gastric lymphoma and adenocarcinoma: a clinicopathological study of 12 patients. Cancer 1997;79:1077– 85

. Lin YL, Wei CK, Chiang JK, Chou AL, Chen CW, Tseng CE. Concomitant gastric carcinoid and gastrointestinal, stromal tumours: a case report. World J Gastroenterol. 2008;14:6100–6103.

. Cirillo F. Neuroendocrine tumours and their association with rare tumours: observation of 4 cases. Eur Rev Med Pharmacol Sci. 2010;14:577–588

. Ramneet Kaur,a Sunita Bhalla,a Samiran Nundy,b and Sunila Jaina ;Synchronous gastric gastrointestinal stromal tumor (GIST) and other primary neoplasms of gastrointestinal tract: report of two cases, Ann Gastroenterol. 2013; 26(4): 356–359.

. Shariq O, Odedra A, Alexopoulos A-S, Gould S, Soobrah R. Synchronous occurrence of gastrointestinal stromal tumour and ovarian neoplasm in a patient presenting with acute cholecystitis. J Gastrointest Cancer. 2012;43:113–116.


  • There are currently no refbacks.




About ASRJETS | Privacy PolicyTerms & Conditions | Contact Us | DisclaimerFAQs 

ASRJETS is published by (GSSRR).