Potential of Indigenous Plants for Skin Healing and Care

  • Anum Javed Department of Zoology, University of Gujrat (Sub campus), 1-KM Daska road, Sialkot, 51310, Pakistan
  • Muhammad Usman Department of Zoology, University of Gujrat (Sub campus), 1-KM Daska road, Sialkot, 51310, Pakistan
  • Syed Muneeb Haider Department of Zoology, University of Gujrat (Sub campus), 1-KM Daska road, Sialkot, 51310, Pakistan
  • Bilal Zafar Department of Zoology, University of Gujrat (Sub campus), 1-KM Daska road, Sialkot, 51310, Pakistan
  • Kainat Iftikhar Department of Zoology, University of Gujrat (Sub campus), 1-KM Daska road, Sialkot, 51310, Pakistan
  • Inzmam -Ul-Haq Department of Zoology, University of Gujrat (Sub campus), 1-KM Daska road, Sialkot, 51310, Pakistan
Keywords: Skin, dermal wounds, injuries, indigenous flora, skin cure.

Abstract

The outer protective layer of body is skin which not only guards it from external fluctuations and effects but also performs its thermoregulation. Its functioning may get affected due to several factors like dermal wounds, injuries, aging and many other disorders. These dermal ailments can be cured with the help of indigenous flora to get economical pharamcognosal benefits with no side effects which is a serious concern of synthetic drugs now days. Furthermore, research efforts are necessary for their proper dose optimization and administration to achieve low cost and side effects free pharamcognosal skin cure and care gains.

References

M. Heinrich, “Ethanobotany and natural products: The search for new molecules, new treatment of old diseases or a better understanding of indigenous cultures.” Current Topics in Medicinal Chemistry, 3, pp. 29-42. 2003.

F. Strodtbeck, “Physiology of wound healing.” Newborn Infant Nurs, 1, pp. 43-45. 2001.

B. Zohreh, R. R. Mohammad, A. S. Mohammad and Z. S. Mohammad, “Medicinal herbs effective on the skin.” Studia Univ. VG, SSV, 24(1), pp. 201-8. 2014.

S. Riahy, H. Imany and A. Khoshbaten, “Effect of topical application of phenytoin and honey in closure of open wound in male rats.” Journal of Army University of Medical Sciences of the Iriran, 7(2), pp. 73-9. 2009.

S. Sormaghi, “Medicinal plants and herbal therapy Tehran: Feeding the world.” 2009.

H. Kinkel, M. Plate and H. Tullner, “Effect of Echinacin ointment in healing of skin lesions.” Med Klinik, 79, pp. 580-3. 1984.

J. Reuter, I. Merfort and C. M. Schempp, “Botanicals in dermatology: an evidence-based review.” Am J Clin Dermatol, 11(4), pp. 247-67. 2010.

S. A. Hashemi, S. A. Madani, and S. Abediankenari, “The review on properties of aloe vera in healing of cutaneous wounds.” BioMed Research International, 2015, 1–6, 2015.

M. Jarahi, M. Zahedi, M. Agorlo and A. Taherian, “Local effect of Aloe barbadensis Miller gel on skin incisional wound healing in rats.” Journal of Gorgan University of Medical Sciences, 11(1), pp. 13-17. 2009.

M. B. Mapunya, R. V. Nikolova, and N. Lall, “Melanogenesis and antityrosinase activity of selected South African plants.” Evidence-Based Complementary and Alternative Medicine, pp. 1-6. 2012.

M. S. Hossain, M. Rashid and M. Nayeem, “A review on ethnopharmacological potential of aloe vera.” Intercult Ethnopharmacol, 2(2), pp. 113-20. 2013.

M. R. Akhoondinasab, M. Akhoondinasab, and M. Saberi, “Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model”. World Journal of Plastic Surgery, 3(1), pp. 29–34. 2014.

P. Sabale, B. Bhimani, C. Prajapati and V. Sabale, “An overview of medicinal plants as wound healers.” Journal of Applied Pharmaceutical Science, 2(11), pp. 143-150. 2012.

S. K. Purohit, R. Solanki, M. K. Soni and V. Mathur, “Experimental evaluation of aloe vera leaves pulp as topical medicament on wound healing.” International Journal of Pharmacological Research, 2(3), pp. 110-112. 2012.

M. Kashanian, M. M. Lakeh, A. Ghasemi and S. Noori, “Evaluation of the effect of vitamin E on pelvic pain reduction in women suffering from primary dysmenorrhea.” Journal of Reproductive Medicine, 58(1), pp. 34–38. 2013.

A. Oryan, A. Mohammadalipour, A. Moshiri, and M. R. Tabandeh, “Topical application of aloe vera accelerated wound healing, modeling and remodeling: an experimental study with significant clinical value.” Annals of Plastic Surgery, 77, pp. 37-46.

S. M. Dalia, J. L. Cervantes and R. Sendon, “Aloe vera : Ancient knowledge with new frontiers.” Trends in Food Science & Technology, 61, pp. 94–102. 2017.

C. W. Cheng, W. L. Chang, L. C. Chang, C. C. Wu, Y. F. Lin and J. S. Chen, “Ferulic acid, an Angelica sinensis-derived polyphenol, slows the progression of membranous nephropathy in a mouse model.” Evid Based Complement Alternat Medicine, 2012.

H. W. Lam, H. C. Lin, S. C. Lao, J. L. Gao, S. J. Hong, C. W. Leong, P. Y. K. Yue, Y. W. Kwan, A. Y. H. Leung, Y. T. Wang and S. M. Y. Lee, “The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo.’ Journal of Cellular Microbiology, 103, pp. 195-211. 2008.

H. Zhao, J. Deneau, G. O. Che, S. Li, F. Vagnini, P. Azadi, R. Sonon, R. Ramjit, S. M. Y. Lee and K. Bojanowski, “Angelica sinensis isolate SBD.4: composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans.” European Journal of Dermatology, 22(1) pp. 58-67. 2012.

J. H. Kim, M. H. Kim, G. Yang, Y. Huh, S. H. Kim and W. M. Yang, “Effects of topical application of Astragalus membranaceus on allergic dermatitis.” Immunopharmacology and Immunotoxicology, 35(1), 151–156. 2012.

X. Chen, L. H. Peng, N. Li, Q. M. Li, P. Li, K. P. Fung, P. C. Leung and J. Q. Gao, “The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo. Journal of Ethnopharmacology, 139(3), pp. 721–727. 2012.

Y. Yang, F. Wang, D. Yin, Z. Fang and L. Huang, “Astragulus polysaccharide-loaded fibrous mats promote the restoration of microcirculation in/around skin wounds to accelerate wound healing in a diabetic rat model.” Colloids and Surfaces B: Biointerfaces, 136, pp. 111–118. 2015.

R. Paul, M. Prasad and N. K. Sah. “Anticancer biology of Azadirachta indica L (neem): a mini review.” Cancer Biology & Therapy, 12(6), pp. 467-476. 2011.

O. Emeka, O. Emamoke, A. Theodore and O. Julius, “The wound healing effects of aqueous leave extracts of Azadirachta indica on wistar rats.” Journal of Natural Science and Research, 3(6). 2013.

S. K. Purohit, R. Solanki, R. Soni, and V. Mathur, “Evaluation of wound healing activity of ethanolic extract of Azadirachta indica leaves in male albino rats”. Asian Journal of Pharmacy and Technology, 3, pp. 73-75. 2013.

A. Singh, A. K. Singh, G. Narayan, T. B. Singh and V. K. Shukla, “Effect of neem oil and haridra on non-healing wounds.” Ayu, 35(4), pp. 398–403. 2014.

N. K. Chundran, I. R. Husen and I. Rubianti, “Effect of Neem leaves extract (Azadirachta Indica) on wound healing.” Althea Medical Journal, 2(2), pp. 199-203. 2015.

M. A. Alzohairy, “Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment.” Evidence-Based Complementary and Alternative Medicine, 2016, 2016.

R. Sharma. “Medicinal Plants of India; An Encyclopaedia,” 33. 2003.

M. B. Raizada and H. O. Saxena, “Flora of Mussoorie.” 1:22. 2012.

S. K. Singh and G. S. Rawat “Flora of Great Himalayan National Park-Himachal Pradesh.” pp. 60-61. 2000.

S. Sultana, M. Ahmad, M. Zafar, M. A. Khan and M. Arshad, “Authentication of herbal drug Senna (Cassia angustifolia Vahl.): A village pharmacy for Indo-Pak Subcontinent.” African Journal of Pharmacy and Pharmacology, 6(30), pp. 2299-2308. 2012.

Y. Yamate, K. Hiramoto and S. Yo, Pharm Biol, 53(6), pp. 913–920. 2015.

B. Brinkhaus, M. Lindner, D. Schuppan and E. G. Hahn, “Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica.” Phytomedicine, 75(5), pp. 427- 448. 2000.

W. Bylka, P. Z. Awizen, E. S. Sroka, A. D. Pazdrowska and M. Brzezińska, “Centella asiatica in dermatology: an overview.” Phytother Res, 28(8). pp. 1117–1124. 2014.

S. S. Rathore, S. N. Saxena and B. Singh, “Potential health benefits of major seed spices.” International J. Seed Spices, 3(2), pp. 1-12. 2013.

J. Gruenwald, T. Brandler and C. Jaenicke, “PDR for herbal medicines, 4th edition.” Philadelphia: Thompson Healthcare; 2007.

B. B. Agarwal, Y. J. Surh and S. Shishodia, “The molecular targets and therapeutic uses of curcumin in health and disease.” Springer, pp. 595, 105–343. 2007.

Shivan and Panday, “Herbs play an important role in the field of cosmetics.” International Journal of Pharmatechnology Research, 2(1):632-635.2010.

J. Mallik and R. Akhter, “Phytochemical screening and in-vitro evaluation of reducing power, cytotoxicity and anti-fungal activities of ethanol extracts of Cucumis sativus.” International Journal of Pharmaceutical & Biological Archives, 3(3), pp. 555-560. 2012.

M. Bhattacharya, A. Singh and C. Ramrakhyani, “Dalbergia sissoo - An important medical plant". Journal of Medical Plants Studies, 2(2), pp. 76-82. 2014.

E. Prochezhian and S. H. Ansari, “Analgesic and anti-inflammatory activity of volatile oil from Daucus carota Linn. Indian J Nat Prod, 16, pp. 24-26. 2000.

M. Hori, “Inhibition of advanced glycation end product formation by herbal teas and its relation to antiaging.” Journal of Antiaging Medicine, 9(6), pp. 135-145. 2012.

C. K. Kang, Y. J. Lee, S. H. Han and S. H. Kim, “Anti-aging cosmetic composition.” Amorepacific Corporation, 2012.

M. Ajaib, S. K. Haider, A. Zikrea and M. F. Siddiqui Int. J. Biol. Biotech, 11(1), pp. 71-83. 2014.

J. A. Gonzalez, M. G. Barriuso and F. Amich, “Ethnobotanical study of medicinal plants traditionally used in the Arribes del Duero, western Spain.” J Ethnopharmacol, 131(2), pp. 343-55, 2010.

A. Clewell, M. Barnes, J. R. Endres, M. Ahmed and D. K. Ghambeer, “Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: A comparative, randomized controlled trial.” J Drugs Dermatol. 11(2), pp. 209-215. 2012.

G. Amin, “The most common traditional medicinal plants in Iran. Tehran: Tehran University of Medical Sciences.” pp. 198. 2005.

J. Reuter, U. Wolfle, S. Weckesser and C. Schempp, “Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex.” J Dtsch Dermatol Ges, 8(10), pp. 788-96, 2010.

F. Casetti, U. Wolfle, W. Gehring and C. M. Schempp, “Dermocosmetics for dry skin: a new role for botanical extracts.” Skin Pharmacol Physiol, 24(6), pp. 289-93. 2011.

B. S. Nayak, G. Isitor, E. M. Davis and G. K. Pillai, “The evidence based wound healing activity of Lawsonia inermis Linn. Phytother Re, 21(9), pp. 827–31. 2007.

B. Fariba, R. Hassan and E. Homeyra, “In vitro study of the effects of henna extracts (Lawsonia inermis on Malassezia species.” Jundishapur J Microbiol, 2010(3), pp. 125–8. 2010.

L. A. Philander, “An ethnobotany of Western Cape Rasta bush medicine.” J. Ethnopharmacol, 138, pp. 578–594. 2011.

F. Gul, Z. A. Shinwari and I. Afzal, “Screening of indigenous knowledge of herbal remedies for skin diseases among local communities of north west punjab, Pakistan”. Pak. J. Bot, 44(5), pp. 1609-1616. 2012.

M. P. Ferreira, F. Gendron, and K. Kindscher, “Bioactive prairie plants and aging adults.” Bioactive Food as Dietary Interventions for the Aging Population, pp. 263–275. 2013.

N. Jabeen, M. Ajaib, M. F. Siddiqui, M. Ulfat, and B. Khan, “A survey of ethnobotanically important plants of district Ghizer, Gilgit-Baltistan.” Fuuast J. Biol, 5(1), pp. 153-160. 2015.

J. N. Sabahi, M. A. Hanif, A. Y. Maskari, M. S. M. Busaidi, M. Y. Maskari and M. H. Haddabi, “Chemical report on wild growing Mentha arvensis and Citrullus colocynthus from Oman”. Journal of Essential Oil Bearing Plants, 19(3), pp. 719-726. 2016.

G. Baba, A. O. Lawal and H. B. Shariff, “Mosquito repellent activity and phytochemical characterization of essential oils from striga hermonthica, hyptis spicigera and ocimum basilicum leaf extracts.” British Journal of Pharmacology and Toxicology, 3(2), pp. 43-48. 2012.

M. Srikanth, T. Swetha and B. Veeresh, “Phytochemistry and pharmacology of oxalis corniculata linn.: a review.” IJPSR, 3(11), pp. 4077-4085. 2012.

D. D. Tibuhwa, “Oxalis corniculata L. in Tanzania: traditional use, cytotoxicity and antimicrobial activities.” Journal of Applied Biosciences, 105, pp. 10055 –10063. 2016.

A. Jain, T. Tiwari and M. Bashir, “Nutritive Aspects of Oxalis corniculata Linn. used by Tribals of Central India During Scarcity of Food”. Botany Research International, 3(1), pp. 35-37. 2010.

V. Singh, N. Shah and D. K. Rana, “Medicinal importance of unexploited vegetable under North Eastern regions of India”. Journal of Medicinal Plants Studies, 3(3), pp. 33-36. 2015.

R. A. Sharma and A. Kumari, “Phytochemistry, pharmacology and therapeutic application of oxalis corniculata linn. - a review”. Int J Pharm Pharm Sci, 3, pp. 6-12. 2014.

K. H. Eddine, S. E. Zerizer and Z. Kabouche, “Immunostimulatory activity of Phoenix dactylifera. Int. J. Pharm. Sci. 6, pp. 73–76. 2014.

H. H. Park, N. Y. Park, S. G. Kim, K. T. Jeong, E. J. Lee and E. Lee, “Potential Wound Healing Activities of Galla Rhois in Human Fibroblasts and Keratinocytes.” American Journal of Chinese Medicine, 43(8), pp. 1625-1636. 2015.

W. Kchaou, F. Abbes, R. B. Mansour, C. Blecker, H. Attia and S. Besbes, “Phenolic profile, antibacterial and cytotoxic properties of second grade date extract from Tunisian cultivars (Phoenix dactylifera L.).” Food Chem, 194, pp. 1048-1055. 2016.

H. Taleb, S. E. Maddocks, R. K. Morris and A. D. Kanekanian, 2016. The Antibacterial Activity of Date Syrup Polyphenols against S. aureus and E. coli. Frontiers in Microbiology, 7, pp. 198. 2016.

B. Yasin, H. E. Fawal and S. Mousa, “Date (Phoenix dactylifera) polyphenolics and other bioactive compounds: a traditional islamic remedy’s potential in prevention of cell damage, cancer therapeutics and beyond. International Journal of Molecular Sciences, 16(12), pp. 30075–30090. 2015.

C. Selmani, D. Chabane and N. Bouguedoura, “Ethnobotanical survey of phoenix dactylifera pollen used for treatment of infertility problems in algerian oases. African Journal of Traditional, Complementary and Alternative Medicines, 14(3), pp. 175–186. 2017.

K. M. Nandkarni’s, “Indian Materia Medica.” Popular Prakasan Pvt. Ltd. Mumbai, 1(3), 2007.

N. Cassano, A. Ferrari, D. Fai, M. Pettinato, S. Pelle and L. D. Brocco, “Oral supplementation with a nutraceutical containing Echinacea, methionine and antioxidant/immunostimulating compounds in patients with cutaneous viral warts.” G Ital Dermatol Venereol. 146, pp. 191–5. 2011.

V. Dwivedi and S. Tripathi, Review study on potential activity of Piper betel. 2014.

S. A. Gilani, R. A. Qureshi, A. M. Khan and D. Potter, “Morphological characterization of the pollen & of the selected species of Genus Prunus Linn. From Northern Pakistan” African Journal of Biotechnology, 9, pp. 2872-2879. 2010.

S. A. Natnoo and J. Mohammed, Reference flora – A source of traditional medicine in Jammu and Kashmir (with special to Chenab valley). International Journal of Recent Scientific Research, 5(12), pp. 2286-2288. 2014.

R. S. Parihaar, K. Bargali and S. S. Bargali, “Diversity and uses of ethno-medicinal plants associated with traditional agroforestry systems in Kumaun Himalaya”. Indian Journal of Agricultural Sciences, 84(12), pp. 1470–1476. 2014.

V. Raj and A. Jain, “Jasmine Chaudhary Prunus armeniaca (Apricot): An Overview.” Journal of Pharmacy Research, 5(8), pp. 3964-3966. 2012.

D. Bown, 2008, “Encyclopedia of Herbs and their uses.” The Royal Horti. Society, London, 18. 2008.

A. C. Brown, M. Hairfield, D. G. Richards, D. L. McMillin, E. A. Mein and C. D. Nelson, “Medical nutrition therapy as a potential complementary treatment for psoriasis – Five case reports.” Altern Med Rev., 9, pp. 297–307. 2014.

Swati and Manoj, Journal of Pharmacognosy and Phytochemistry, 7(1), pp. 371-376. 2018.

L. U. Araujo, P. G. Reis, L. C. Barbosa, D. A. S. Guimaraes, A. G. Guimaraes, V. C. Mosqueira, C. M. Carneiro and N. M. S. Barcellos, “In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations.” Pharmazie, 67, pp. 355–360. 2012.

C. Staiger 2012. “Comfrey: a clinical overview. Phytother Res., 26:1441–1448.

R. Frost, H. MacPherson and S. O’Meara,“A critical scoping review of external uses of comfrey (Symphytum spp.).” Complement Ther Med, 21, pp. 724–745. 2013.

H. Benamar, L. Tomassini, A. Venditti, A. Marouf, M. Bennaceur, M. Serafini and M. Nicoletti, “Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy.” Nat Prod Res., 31, pp. 1277–1285. 2017.

P. Kuru, “Tamarindus indica and its health related effects.” Asian Pacific Journal of Tropical Biomedicine, 4(9), pp. 676-681. 2014.

S. S. Bhadoriya, A. Ganeshpurkar, J. Narwaria, G. Rai A. P. Jain, “Tamarindus indica: extent of explored potential.” Pharmacogn Rev, 5(9), pp. 73-81. 2011.

D. Gupta and U. Nautiyal, “Ayurvedic remedies for healing of wounds: A Review.” Int. J. Pharm. Med. Res., 4(4), pp. 342-349. 2016.

I.R. Fahmy and H. Abu-Shady,” The isolation and properties of ammoidin, ammidin and majudin and their effect in the treatment of leukodermia”. Q J Pharm Pharmacol. 21, pp. 499-503. 1984.

C. Circosta, R. Pasquale, D. R. Palumbo, S. Samperi and F. Occhiuto, “Effect of isoflavones from Red Clover (Trifolium pratense L.) on skin changes induced by ovariectomy in rats.” Phytother, 20, pp. 1096–1099. 2006.

M. Lipovac, P. Chedraui, C. Gruenhut, A. Gocan, C. Kurz, B. Neuber and M. Imhof, (2011) “Effect of red clover isoflavones over skin, appendages, and mucosal status in postmenopausal women.” Obstet Gynecol Int, 949302. 2011.

E. Loing, R. Lachance, V. Ollier and M. Hocquaux, “A new strategy to modulate alopecia using a combination of two specific and unique ingredients.” J Cosmet Sci, 64(1), pp. 45-58. 2013.

A. C. Dweck, “The internal and external use of medicinal plants.” Clinics in Dermatolog, vol. 27(2), pp. 148–158. 2009.

P. Chauhan, “Skin cancer and role of herbal medicines”. Asian Journal of Pharmacy and Pharmacology, 4(4), pp. 404-412. 2018.

S. N. Acharya, J. E. Thomas and S. K. Basu, “Fenugreek, an alternative crop for semiarid regions of North America.” Crop Sci, 48, pp. 841-53. 2008.

S. K. Basu, S. N. Acharya and J. E. Thomas, “Application of phosphate fertilizer and harvest management for important fenugreek (Trigonella foenum-graecum L.) seed and forage yield in a dark brown soil zone of Canada.” KMITL Sci Tech J, 8(1), pp. 1 –7. 2008.

S. Kapoor and S. Saraf, “Assessment of viscoelasticity and hydration effect of herbal moisturizers using bioengineering techniques.” Phcog Mag, 6, pp. 298- 304, 2010.

S. Guillou, S. Ghabri, C. Jannot, E. Gaillard and I. Lamour, “The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial.” Int J Cosmet Sci, vol. 33(2), pp. 138-43, 2011.

A. Mastroianni, L. Celleno and M. G. Borgia, “Lestratto acquoso di ‘’Triticum vulgare’’- valutazione clinico-istologica Nei processi riparativi tissutali cutanei.” G Ital .Derm. Venereol, 133, pp.145-153. 1988.

R. Bandopadhyay, S. Rustgi and K. Chaudhuri, “Use of methylation filtration and C0t fractionation for analysis of genome composition and comparative genomics in bread wheat.” J. Genet and Genom, 38, pp. 315-325. 2011.

A. A. Hemmati, M. Foroozen, G. Houshmand, Z. B. Moosavi, M. Bahadoram and N. S. Maram, “The topical effect of grape seed extract 2% cream on surgery wound healing.” Global Journal of Health Science, 7(3), 2015.

K. L. Keller, and N. A. Fenske, “Uses of vitamins A, C, and E and related compounds in dermatology: a review.” J Am Acad Dermatol, 39, pp. 611-625, 1998.

B. N. Ames, “Dietary carcinogens and anticarcinogens.” Science, 221, pp. 1256-1264, 1983.

S. K. Katiyar and H. Mukhtar, “Tea antioxidants in cancer chemoprevention.” J Cell Biochem, 27, pp. 59–67. 1997.

R.E. Hakim, “Rediscovery of a treatment for vitiligo”. Clio Medica. 4, pp. 277- 289. 1969.

A. Javed, “Evaluation of ethanolic crude extracts of Azadirachta indica and Solanum nigrum efficacy for dermal wounds healing”. JIARM, 5(8): pp. 01-11. 2017.

A. Javed and J.I. Qazi, “Efficacy of Azadirachta indica and Solanum nigrum for skin regeneration in mice”. Pak. J. life Soc. Sci., 14(3): pp. 158-166. 2016.

A. Javed and A. Kabeer, “Implication of flora for skin wound healing and regeneration from Pakistan”. IJCR, 10 (06): pp. 639383-88. 2018.

A. Javed, “Edge of herbal preparations for skin regeneration over synthetic ointments”. IJRSR, 7(8): pp. 13012-17. 2016.

E. S. Yahayaa, W. Cordiera , P. A. Steenkampc and V. Steenkampa , “Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa. Journal of Pharmacy and Pharmacology, 70, pp. 111–123. 2018.

S. Mishra, V. Aeri, P. K. Gaur and S. M. Jachak, “Phytochemical, Therapeutic, and Ethnopharmacological Overview for a Traditionally Important Herb: Boerhavia diffusa Linn”. BioMed Research International, 1- 19. 2014.

G; Näf, U. E. Gasser, H. E. Holzgang, S. Schafroth, C. Oehler and D. R. Zwahlen, “Prevention of Acute Radiation-Induced Skin Reaction with NPED Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Single Centre, Prospective, Open-Label Pilot Study”. International Journal of Breast Cancer, pp. 1-9. 2018.

Y.H. Lin, and L.I. Cheng-Shing, “Method for protecting skin by using Camellia sinensis callus extract.” US Patent App. 15/918,979. 2018.

S.C. Gupta, T. Tripathi, S.K. Paswan, A.G. Agarwal, C.V. Rao and O.P. Sidhu, “Phytochemical investigation, antioxidant and wound healing activities of Citrullus colocynthis (bitterapple)”. Asian Pacific Journal of Tropical Biomedicine, 8 (8) pp. 418-424. 2018.

X. Han, C. Beaumont, N. Stevens and T.L. Parker, “Chemical composition analysis and in vitro biological activities of ten essential oils in human skin cells. Biochimie Open, 5, pp. 1-7, 2017.

S. M. R. Javadi, M. Hashemi, Y. Mohammadi, A. MamMohammadi, A. Sharifi and H. R. Makarchian, “Synergistic effect of honey and Nigella sativa on wound healing in rats.” Acta Cir. Bras. 33(6), pp. 518-523. 2018.

Yunita Sari, Iwan Purnawan, Dhadhang Wahyu Kurniawan and Eman Sutrisna, “A comparative study of the effects of Nigella sativa oil gel and aloe vera gel on wound healing in diabetic rats.” Journal of Evidence-Based Integrative Medicine, 23, pp. 1-6.

Singh, K.; Jaggi, A.S.; Singh, N. Exploring the ameliorative potential of Punica granatum in dextran sulfate sodium induced ulcerative colitis in mice. Phytother. Res. 2009, 23, 1565–1574.

Türkyilmaz, M.; Tagi, S.; Dereli, U.; Ozkan, M. Effects of various pressing programs and yields on the antioxidant activity, antimicrobial activity, phenolic content and colour of pomegranate juices. Food Chem. 2013, 138, 1810–1818.

Kaur, G.; Jabbar, Z.; Athar, M.; Alam, A.S. Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem. Toxicol. 2006, 44, 984–993.

Nayak, S.B.; Rodrigues, V.; Maharaj, S.; Bhogadi, V.S. Wound healing activity of the fruit skin of Punica granatum. J. Med. Food 2013, 16, 857–861.

Ma, K.; Du, M.; Liao, M.; Chen, S.; Yin, G.; Liu, Q.; Wei, Q.; Qin, G. Evaluation of wound healing effect of Punica granatum L. peel extract on deep second-degree burns in rats. Trop. J. Pharm. Res. 2015, 14, 73–78.

Hayouni, E.A.; Miled, K.; Boubaker, S.; Bellasfar, Z.; Abedrabba, M.; Iwaski, H.; Oku, H.; Matsui, T.; Limam, F.; Hamdi, M. Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomed 2011, 18, 976–984.

Machado, T.B.; Leal, I.C.R.; Amaral, A.C.F.; Santos, K.R.N.; Silva, M.G.; Kuster, R.M. Antimicrobial ellagitannins of Punica granatum fruits. J. Braz. Chem. Soc. 2002, 13, 606–610.

Y. Yang, J. Xiu, L. Zhang, C. Qin, J. Liu, “Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo.” Phytomed, 20, 67–70. 2012.

A. Fleck, P. F.G. Cabral, F.F.M. Vieira, D.A. Pinheiro, C.R. Pereira, W.C. Santos and T.B. Machado, “Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization”. Molecules, 21(1059), 1-13. 2016.

Published
2019-01-24
Section
Articles