Olfactometry in Patients with Certain Endocrine Diseases

  • Budin Mihov Hospital of Neurology and Psychiatry “Sv. Naum”, Medical University – Sofia
Keywords: Olfactometry, prolactinoma, acromegaly, hypothyroidism, hyperthyroidism.

Abstract

The endocrine system affects the function of many organs and systems. Some endocrine disorders damage the nervous system and the sensory systems. The aim of this study was to identify changes in the sense of smell in some endocrine diseases: prolactinoma, acromegaly, hypothyroidism and hyperthyroidism. The sense of smell in four groups of patients with these diseases was examined and compared with that of a group of healthy controls. For testing and evaluating the sense of smell, the olfactometer of Dimov-Raykov was used. In the four groups, we observed reduced sense of smell compared to the control group. We have found significant deviations in patients with acromegaly and prolactinoma. In other two groups of patients with hyperthyroidism and hypothyroidism, we established also weak pathological deviations; however they have no statistical significance.

References

[1]. Caruso S, Grillo C, Agnello C, Mari A, Farina1 M, Serra A. Olfactometric and rhinomanometric outcomes in postmenopausal women treated with hormone therapy: a prospective study. Human Reproduction, 2004, 12, 2959-2964.
[2]. Savović S, Nincić D, Lemajić S, Pilija V, Mandić A, Rajović J, Ivetić V. [Olfactory perception in women with physiologically altered hormonal status (during pregnancy and menopause]. Med Pregl. 2002, 55, 380-383.
[3]. Woo CC. Neurological features of acromegaly: a review and report of two cases. J Manipul Physiol Ther, 1988, 11, 314-321.
[4]. Enoksson P. A study of the visual fields with white and coloured objects in cases of pituitary tumour with especial reference to early diagnosis. Acta Ophthalmol, 1953, 31, 505-515.
[5]. Bucurescu G., Lorenzo N. Neurological manifestations of thyroid disease clinical presentation. Medscape, 2005 < http://emedicine.medscape.com/article/1172273-clinical>
[6]. Dimov D. Vkus i obonyanie [Taste and sense of smell]. Medicina i Fiskultura, Sofia, 1985.
[7]. Mathias CJ. Autonomic diseases: clinical features and laboratory evaluation. J Neurol Neurosurg Psychiatry, 2003, 74, 31-41.
[8]. Siddiqui NI, Chowdhury KS, Rahman S, Sarker CB, Rahman KM. A case of acromegaly. Mymensingh Med J, 2003, 12, 58-60.
[9]. Dutta P, Hajela A, Pathak A, Bhansali A, Radotra BD, Vashishta RK, Korbonits M, Khandelwal N, Walia R, Sachdeva N, Singh P, Murlidharan R, Devgun JS, Mukherjee KK. Clinical profile and outcome of patients with acromegaly according to the 2014 consensus guidelines: Impact of a multi-disciplinary team. Neurol India, 2015, 3, 360-368.
[10]. Torner L. Actions of prolactin in the brain: From physiological adaptations to stress and neurogenesis to psychopathology. Front Endocrinol, 2016, 30, 7-25.
[11]. Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ. The clinical characteristics of headache in patients with pituitary tumours. Brain, 2005, 128, 1921-1930.
Published
2017-02-25
Section
Articles