Development and Characterization of Nisoldipine Matrix Type Transdermal Films; In vitro and Ex-vivo Evaluation

Authors

  • Gayatri. P Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, 506005,Warangal, India.
  • Ajitha. M Centre for pharmaceutical sciences, IST, JNTUH, 500072, Hyderabad, India.
  • Pavan Kumar.P Dr. Reddys Laboratories Limited , Bachupally, 500090, Hyderabad , India.
  • Madhusudan Rao.Y Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, 506005,Warangal, India.

Keywords:

Nisoldipine, Matrix films, Mechanical properties, In vitro drug release, Ex –vivo skin permeation, Release kinetics.

Abstract

The purpose of this study was to fabricate the transdermal films of a low oral bioavailability drug Nisoldipine (5%) employing a combination of hydrophilic and hydrophobic polymer. The films were developed by solvent evaporation technique. The polymeric matrix contains Ethyl cellulose/Eudragit RS 100 and HPMC E-15. The effect of hydrophilic and hydrophobic polymers on the physicochemical and mechanical properties, such as weight variation, thickness, moisture uptake, moisture content, and tensile strength, elongation at break was evaluated.  In-vitro release and ex-vivo permeation across the rat skin was studied using the Franz diffusion cells. The tensile strength of the NS6 and NSE5 were found to be 0.9±0.21 and 1.9±0.10 kg/mm2.The films developed in the ratio of 15:5 (NS6) and 12.5:7.5 (NSE5) using HPMC E15-ERS 100 and HPMCE15- EC showed maximum drug release and ex-vivo permeation (NS6: 953 µg and NSE5:895 µg).The flux of NS6 and NSE5 was 13.03 µg/cm2/hr and 11.77 µg/cm2/hr. The data of release kinetics using different kinetic models indicated that release from optimized formulations followed zero order release kinetics with non fickian diffusion pattern.  FTIR studies revels that there was no interaction between the drug and polymer and were found to be compatible. Matrix type transdermal films can be fabricated employing hydrophilic and hydrophobic polymers with suitable mechanical properties.

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Published

2016-07-31

How to Cite

P, G., M, A., Kumar.P, P., & Rao.Y, M. (2016). Development and Characterization of Nisoldipine Matrix Type Transdermal Films; In vitro and Ex-vivo Evaluation. American Scientific Research Journal for Engineering, Technology, and Sciences, 23(1), 1–14. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/1823

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