Vitamin D Deficiency and Risk of Uterine Leiomyoma among Congolese Women. A Hospital-Based Case-Control Study

Authors

  • P Ingala Department of Obstetrics and Gynecology, University of Kinshasa Hospital,Kinshasa,00243,Démocratic Republic of Congo.
  • J Mboloko Department of Obstetrics and Gynecology, University of Kinshasa Hospital,Kinshasa,00243,Démocratic Republic of Congo.
  • A Tshiband Dvision of Radioimmunology, Regional Center of Nuclear Study of Kinshasa, Kinshasa,00243,Démocratic Republic of Congo.
  • F Lepira Department of Internal Medicine, University of Kinshasa ,Kinshasa,00243,Démocratic Republic of Congo.
  • P Kayembe Public Health School of Kinshasa ,Kinshasa,00243,Democratic Republic of Congo.
  • B Lebwaze Department of Pathology, University Of Kinshasa,Kinshasa,00243,Démocratic Republic of Congo.
  • A Mputu Department of Obstetrics and Gynecology, University of Kinshasa Hospital,Kinshasa,00243,Démocratic Republic of Congo.

Keywords:

Vitamin D Deficiency, Uterine Leiomyoma, Congolese Women.

Abstract

The aim of the present study was to assess the relationship, between Vitamin D deficiency and uterine leiomyoma in Congolese women.

From April 1 to October 31, 2014, 216 patients with ultrasound diagnosis of uterine leiomyoma (cases) and 216 women without this condition (controls) recruited in six medical facilities in Kinshasa were enrolled in the present study. A single blood sample was obtained from all participants to assess serum17?-estradiol and progesterone concentration using RIA and 25(OH) D by IRMA. Vitamin D deficiency was defined as 25(OH) D levels <4 ng/mL and <12 ng/mL using local and IOM cut-off levels, respectively. Chi square, Student t and Mann Whitney tests were used for group comparison. Logistic regression analysis was used to identify factors associated with Vitamin D deficiency. Vitamin D deficiency was observed in 17.1% and 47.7% of patients with ULM using local and IOM criteria defining different steps of vitamin D respectively. Compared to controls, the difference was statistically significant only when using local criteria (17.7% vs 10.2%; p = 0.028).

ULM main risk factors were age ?35 years (aOR=2,974; 95%CI 1,702-5,139; p = 0,001); null parity (aOR=3,951;95%CI 2,311-6,754;  p= 0,001). Familial history of ULM (aOR=2,619; 95% CI 1,376-4,986; p =0,003) personal history of ULM a(OR3,776; 95% CI 1,885-7,565;  p=0,001); absence of menopause(OR5,502; 95% CI 2,615-11,517; p= 0,001); high serum progesterone levels (aOR 2,320 95% CI1,136-4,711; p= 0,021),   alcohol consumption  (aOR0,295; 95 % CI 0,150-0,580; p= 0,001) and Vitamin D deficiency(aOR2,153; 95% CI 1,035-4,517; p=  0,040).  Vitamin D deficiency was a common finding in patients with ULM and emerged as one of the main risk factors. However, this relationship need to be confirmed with a representative sample of women with ULM.

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Published

2016-07-22

How to Cite

Ingala, P., Mboloko, J., Tshiband, A., Lepira, F., Kayembe, P., Lebwaze, B., & Mputu, A. (2016). Vitamin D Deficiency and Risk of Uterine Leiomyoma among Congolese Women. A Hospital-Based Case-Control Study. American Scientific Research Journal for Engineering, Technology, and Sciences, 22(1), 126–137. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/1759

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