The Synergistic Effect of Two Remedial Plant Extracts on Hyperglycemia and Selected Associated Complications in Streptozotocin-induced Rats
Keywords:
Plants extract, Diabetes, weight gain, blood pressure, animal modelAbstract
The study investigated the synergistic effects of remedial plant extracts from Musa accuminata (banana) and Momordica charantia (bitter melon) on hyperglycemia and associated complications in streptozotocin-induced diabetic rats—a widely accepted model for studying diabetes mellitus and its complications. Diabetes mellitus, characterised by elevated blood glucose levels and potential organ system complications, prompted the exploration of herbal remedies with minimal adverse effects. Rats induced with diabetes were treated with Musa accuminata extract, Momordica charantia extract, and a combination of both extracts. Blood glucose levels were monitored, and markers of complications, including blood pressure and weight management, were assessed.
Results revealed that the combined treatment demonstrated a synergistic effect, effectively lowering blood glucose levels (350.43±0.14 to 291.59±23.26) compared to individual extract treatments: Banana extract, Bitter melon extract and Glibenclamide (350.43±0.10 to 300.39±21.02, 347.34±0.06 to 292.23±24.53 and 348.30±0.12 to 287.64±24.06) respectively. Furthermore, the combined treatment exhibited significant improvements in blood pressure (127.92/91.25mmHg, 129.19/98.06, 127.20/99.58mmHg and 130.75/99.83mmHg, combined extract, banana bitter melon and Glibenclamide respectively) and weight management in the animal model, surpassing the outcomes of glibenclamide and untreated diabetic rats. The average weight gain across all the groups ranges from 250g to 321g per rat.These findings highlight the potent anti-hyperglycemic and anti-complication properties of the Musa accuminata and Momordica charantia extracts and their combination in streptozotocin-induced diabetic rats. It is suggested that additional research be done on the underlying mechanisms and clinical trials to confirm the plant extracts' medicinal potential in treating diabetes mellitus and its related problems.
References
J. Speight, E. Holmes-Truscott, C. Hendrieckx, S. Skovlund, and D. Cooke, “Assessing the impact of diabetes on quality of life: what have the past 25 years taught us?,” Diabetic Medicine, vol. 37, no. 3. Blackwell Publishing Ltd, pp. 483–492, Mar. 01, 2020. doi: 10.1111/dme.14196.
L. J. Muhammad, E. A. Algehyne, and S. S. Usman, “Predictive Supervised Machine Learning Models for Diabetes Mellitus,” SN Comput Sci, vol. 1, no. 5, Sep. 2020, doi: 10.1007/s42979-020-00250-8.
L. J. Muhammad, E. A. Algehyne, and S. S. Usman, “Predictive Supervised Machine Learning Models for Diabetes Mellitus,” SN Comput Sci, vol. 1, no. 5, Sep. 2020, doi: 10.1007/s42979-020-00250-8.
G. E. Enoyoze, M. Idu, and B. O. Gabriel, “Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats,” Journal of Current Biomedical Research, vol. 2, no. 5, September-October, pp. 456–474, Oct. 2022, doi: 10.54117/jcbr.v2i5.5.
O. M. Lage, M. C. Ramos, R. Calisto, E. Almeida, V. Vasconcelos, and F. Vicente, “Current screening methodologies in drug discovery for selected human diseases,” Marine Drugs, vol. 16, no. 8. MDPI AG, Aug. 14, 2018. doi: 10.3390/md16080279.
U. Anand, N. Jacobo-Herrera, A. Altemimi, and N. Lakhssassi, “A comprehensive review on medicinal plants as antimicrobial therapeutics: Potential avenues of biocompatible drug discovery,” Metabolites, vol. 9, no. 11. MDPI AG, Nov. 01, 2019. doi: 10.3390/metabo9110258.
Oyinloye O.D, Akinyele A, Osinubi O, and Ajani A, “A COMPARATIVE STUDY ON THE MICRONUTRIENTS COMPOSITION OF WATERMELON SEED AND WILD MELON SEED (EGUSI),” Sciences, Engineering & Environmental Technology (ICONSEET), vol. 6, no. 34, pp. 276–281, 2021, [Online]. Available: www.repcomseet.com
M. M. A. K. Khattak et al., “Antidiabetic activity evaluation of polyherbal formulation in type 2 diabetes mellitus patients,” J King Saud Univ Sci, vol. 36, no. 1, Jan. 2024, doi: 10.1016/j.jksus.2023.103010.
M. M. A. K. Khattak et al., “Antidiabetic activity evaluation of polyherbal formulation in type 2 diabetes mellitus patients,” J King Saud Univ Sci, vol. 36, no. 1, Jan. 2024, doi: 10.1016/j.jksus.2023.103010.
S. F. Spampinato, G. I. Caruso, R. De Pasquale, M. A. Sortino, and S. Merlo, “The treatment of impaired wound healing in diabetes: Looking among old drugs,” Pharmaceuticals, vol. 13, no. 4, Apr. 2020, doi: 10.3390/ph13040060.
A. Artasensi, A. Pedretti, G. Vistoli, and L. Fumagalli, “Type 2 diabetes mellitus: A review of multi-target drugs,” Molecules, vol. 25, no. 8. MDPI AG, Apr. 01, 2020. doi: 10.3390/molecules25081987.
M. Hasanpour, M. Iranshahy, and M. Iranshahi, “The application of metabolomics in investigating anti-diabetic activity of medicinal plants,” Biomedicine and Pharmacotherapy, vol. 128. Elsevier Masson SAS, Aug. 01, 2020. doi: 10.1016/j.biopha.2020.110263.
Oyinlloye O. D, “THE EFFECT OF COOKING POTS ON THE MINERAL CONTENT OF LAGOS SPINACH (CELOSIA ARGENTEA),” Sciences, Engineering & Environmental Technology (ICONSEET), vol. 6, no. 37, pp. 298–304, 2021, [Online]. Available: www.repcomseet.com
D. Bhattacharjee et al., “A SYSTEMATIC REVIEW ON MOMORDICA CHARANTIA,” Certified Journal ? Bhattacharjee et al. World Journal of Pharmaceutical Research, vol. 11, 2022, doi: 10.20959/wjpr202216-26385.
K. H. Maseko, T. Regnier, B. Meiring, O. C. Wokadala, and T. A. Anyasi, “Musa species variation, production, and the application of its processed flour: A review,” Scientia Horticulturae, vol. 325. Elsevier B.V., Feb. 01, 2024. doi: 10.1016/j.scienta.2023.112688.
D. Bhattacharjee et al., “A SYSTEMATIC REVIEW ON MOMORDICA CHARANTIA,” Certified Journal ? Bhattacharjee et al. World Journal of Pharmaceutical Research, vol. 11, 2022, doi: 10.20959/wjpr202216-26385.
N. Kumar, A. Ved, R. R. Yadav, and O. Prakash, “A Comprehensive Review on Phytochemical, Nutritional, and Therapeutic Importance of Musa acuminate,” Int J Curr Res Rev, vol. 13, no. 09, pp. 114–124, 2021, doi: 10.31782/ijcrr.2021.13901.
Y. C. Cheng, Y. M. Chiu, Z. K. Dai, and B. N. Wu, “Loganin ameliorates painful diabetic neuropathy by modulating oxidative stress, inflammation and insulin sensitivity in streptozotocin-nicotinamide-induced diabetic rats,” Cells, vol. 10, no. 10, Oct. 2021, doi: 10.3390/cells10102688.
S. S. Ramya, N. Vijayanand, B. Ponnerulan, E. Saminathan, U. Veeranan, and D. Kathiresan, “PHYTOCHEMICAL SCREENING, HPTLC ANALYSIS AND ANTIDIABETIC POTENTIAL OF TRIGONELLA FOENUM GRAECUM ON ALLOXAN INDUCED DIABETIC RATS,” 2020.
D. Dah-Nouvlessounon et al., “Ethnopharmacological Value and Biological Activities via Antioxidant and Anti-Protein Denaturation Activity of Morinda lucida Benth and Momordica charantia L. Leaves Extracts from Benin,” Plants, vol. 12, no. 6, Mar. 2023, doi: 10.3390/plants12061228.
Z. Liu, M. Bai, H. Tan, Y. Ling, and Z. Cao, “Experimental test on the performance of a ?80 °C cascade refrigeration unit using refrigerants R290-R170 for COVID-19 vaccines storage,” Journal of Building Engineering, vol. 63, Jan. 2023, doi: 10.1016/j.jobe.2022.105537.
M. Niamul Shahadat, R. Islam, M. Misrat Masuma Parvez, and S. Sarkar, “Antidiabetic Evaluations of some Traditional Plants in Alloxan Induced Diabetic Mice Model,” Issue 12 Ser. I, vol. 12, pp. 59–68, 2019, doi: 10.9790/2380-1212015968.
T. Behl et al., “Alkaloidal Phytoconstituents for Diabetes Management: Exploring the Unrevealed Potential,” Molecules, vol. 27, no. 18. MDPI, Sep. 01, 2022. doi: 10.3390/molecules27185851.
Oyinloye O D, Adesina I A, and Oyinloye F F, “PERCEIVED IMPACT OF EXCLUSIVE BREASTFEEDING ON JOB PERFORMANCES AMONG WORKING-CLASS NURSING MOTHERS IN GENERAL HOSPITAL IFAKO IJAYE, LAGOS,” International Journal of Sciences, Engineering & Environmental Technology (IJOSEET), vol. 7, no. 16, pp. 146–153, 2022, [Online]. Available: www.repcomseet.org
Oyinloye OD, Akande NO, Osinubi OB, Ajani AA, Abdulkareem SA, and Oyinloye FF, “EVALUATION OF BREAD MADE FROM WHEAT AND COMPOSITE FLOURS OF SWEET POTATO,” International Journal of Sciences, Engineering & Environmental Technology (IJOSEET), vol. 7, no. 14, pp. 128–136, 2022, [Online]. Available: www.repcomseet.org
J. Rana, J. Rana, V. Prakash, and A. Sagar, “STATUS OF INDIAN MEDICINAL PLANTS IN TERMS OF ANTIOXIDANT ACTIVITY (IN VITRO),” Plant Arch, vol. 21, no. No 1, Apr. 2021, doi: 10.51470/plantarchives.2021.v21.no1.100.
S. Parasuraman and R. Raveendran, “Measurement of invasive blood pressure in rats,” J Pharmacol Pharmacother, vol. 3, no. 2, pp. 172–177, Apr. 2012, doi: 10.4103/0976-500X.95521.
M. Toral et al., “Critical role of the interaction gut microbiota-sympathetic nervous system in the regulation of blood pressure,” Front Physiol, vol. 10, no. MAR, 2019, doi: 10.3389/fphys.2019.00231.
L. Huang et al., “Effect of dose and duration of reduction in dietary sodium on blood pressure levels: Systematic review and meta-analysis of randomised trials,” The BMJ, vol. 368. BMJ Publishing Group, Feb. 24, 2020. doi: 10.1136/bmj.m315.
T. M. Nyambuya et al., “A meta-analysis of the impact of resveratrol supplementation on markers of renal function and blood pressure in type 2 diabetic patients on hypoglycemic therapy,” Molecules, vol. 25, no. 23, Dec. 2020, doi: 10.3390/molecules25235645.
F. Sapna et al., “Advancements in Heart Failure Management: A Comprehensive Narrative Review of Emerging Therapies,” Cureus, Oct. 2023, doi: 10.7759/cureus.46486.
Y. Shen et al., “Searching for optimal blood pressure targets in type 2 diabetic patients with coronary artery disease,” Cardiovascular Diabetology, vol. 18, no. 1. BioMed Central Ltd., Nov. 16, 2019. doi: 10.1186/s12933-019-0959-1.
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