Spectrum of Lipid Profile among Cancer Patients: Pre and Post Treatment Analysis, a Prognostic Factor Determining Quality of Life
Keywords:
Cancer, Lipid profile, Pre-Post treatment analysisAbstract
The objective of the study was to analyze the lipid profile among cancer patients and their pre and post treatment evaluation to monitor the effect of Lipids in cancer progression.It was a retrospective observational study conducted at Shaukat Khanum Memorial Cancer Hospital from January 1st 2023 to January 1st 2025. Serum samples of 392 patients were included in the study that were already analysed on automated chemistry analyser Atellica for serum lipid profile along with two levels of Quality Control by BioRad. The lipid profile included serum total cholesterol, triglyceride (TGs), low-density lipoprotein (LDL), and high-density lipoproteins (HDL). Kolmogrov’s Smirnov test was applied for normality. For pre-post treatment comparison, Wilcoxon rank sum test was used. The data was analysed using SPSS version 29. The results showed that about 63% females participated compared to 37% males. Participants were put in four age groups and lipid parameters were highest in the age group of 26-40. Breast carcinoma was the most frequent (41%) followed by CA Colon (7.4%). There was a significant difference (P value< 0.005) in lipid parameters pre and post-treatment except HDL-C (P value=0.538). We also found a significant difference in serum lipids with highest and the lowest value of LDL-C in CA Breast and CA kidney (116 ± 38.9 vs 89 ± 33.1). It was concluded that for early monitoring of the disease, patients can be grouped as low and high risk depending on their LDL levels. Furthermore, LDL-C proved to be a target for treatment in cancer patients for restricting the growth and progression of the disease.
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