Formulation & Evaluation of Fluconazole Gel for Topical Drug Delivery System

Authors

  • Arjun Gaire B.Pharm Shree Medical & Technical College, QA Officer, Kasturi Pharmaceuticals Pvt. Ltd.Bharatpur-16, Chtiwan.
  • Sangit Maharjan B.Pharm (Clinical pharmacy) Pokhara University, Quality Control Officer, Divine Healthcare Pvt. Ltd. Bharatpur-16, Chitwan.
  • Sumitra Shrestha M.Pharm (Clinical pharmacy) Pokhara University, Assistant Quality Assurance Manager Divine Healthcare Pvt. Ltd. Bharatpur-16, Chitwan.
  • Sonu Pakhrin M.Pharm (Clinical pharmacy) Pokhara University, Quality Control Officer, Divine Healthcare Pvt. Ltd. Bharatpur-16, Chitwan.
  • Naresh Thapa B.Pharma Dhaka University, Bangladesh, Quality Assurance Manager Divine Healthcare Pvt. Ltd. Bharatpur-16, Chitwan
  • Dr. Jeevan Raj Shrestha BSC (Microbiology), MBBS (Manipal College of Medical Sciences, Pokhara, NepalSangit
  • Mrs. Bijaya Laxmi Giri M.Pharm (Industrial pharmacy) Kathmandu University, Assistant Professor, Shree Medical and Techincal College, Bharatpur-10, Chitwan.

Keywords:

Fluconazole, Carbopol 940, Sodium Carboxy Methyl Cellulose, Topical Drug delivery system

Abstract

Fluconazole is a recent triazole antifungal drug that is used in the treatment of superficial and systemic fungal infection. The oral use of fluconazole is not much recommended as it has many side effects. Thus this formulation is made for better patient compliance and to reduce the dose of the drug and to avoid the side effects like liver damage and kidney damage. This research was designed to formulate & evaluate different formulation of a topical gel containing fluconazole by using a polymer with different concentration as Carbopol 940 & NaCMC. Methanol was used as a penetration enhancer. The evaluation of formulated fluconazole topical gel was carried out for a physical appearance, pH-value, spreadability, homogeneity, drug content. The formulated gel showed good physical characteristics. The formulation F3 (101.18%) & F6 (105.4%) show good drug content as the polymer concentration in them was higher. The percentage yield of F4 (98.26%) was the highest. The spreadability of gel decreases with an increase in polymer concentration. The pH of the formulation was in the range of 5-8 which is considered acceptable to avoid the risk of irritation upon application to the skin.

References

. Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes—novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. Journal of controlled release. 2000;65(3):403-18.

. Dhandore SG, Wagh KB. Formulation and evaluation of fluconazole gel by using synthetic polymer. PharmaTutor. 2018;6(4):27-31.

. Glavas-Dodov M, Fredro-Kumbaradzi E, Goracinova K, Calis S, Simonoska M, Hincal AA. 5-Fluorouracil in topical liposome gels for anticancer treatment--formulation and evaluation. Acta pharmaceutica (Zagreb, Croatia). 2003;53(4):241-50.

. Rupal J, Kaushal J, Mallikarjuna SC, Dipti P. Preparation and evaluation of topical gel of valdecoxib. International Journal of Pharmaceutical Sciences and Drug Research. 2010;2(1):51-4.

. Fink G. the Fink lab. How antifungal drug kill fungi and cure disease(Online). 2005.

. Indora N, Kaushik D. Design, development and evaluation of ethosomal gel of fluconazole for topical fungal infection. International journal of engineering science invention research & development. 2015;1(8):280-306.

. Bangarwa S, Garg S, Aseri A. A review on antifungal gels: as a topical drug delivery system. Int J Pharm Technol Biotechnol. 2014;1:48-55.

. Song JC, Deresinski S. Hepatotoxicity of antifungal agents. Current opinion in investigational drugs (London, England: 2000). 2005;6(2):170.

. Kasar PM, Kale KS, Phadtare DG. Formulation and Evaluation of Topical Antifungal Gel Containing Itraconazole. Research Journal of Topical and Cosmetic Sciences. 2018;9(2):49-52.

. JAIN BD. FORMULATION DEVELOPMENT AND EVALUATION OF FLUCONAZOLE GEL IN VARIOUS POLYMER BASESFORMULATION DEVELOPMENT AND EVALUATION OF FLUCONAZOLE GEL IN VARIOUS POLYMER BASES. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm. 2016;1(1).

. Pharmacopoeia B. International Publication. Vol II. 1993.

. Rathod HJ, Mehta DP. A review on pharmaceutical gel. International Journal of Pharmaceutical Sciences. 2015;1(1):33-47.

. Parashar B, Kabra A, Chandel A. Formulation and evaluation of gel containing Miconazole nitrate an antifungal agent. Int J Pharm Res Rev. 2013;2(6):18-28.

. Soni A, Chaudhary A, Singla S, Goyal S. Review on: Novel Approach in Pharmaceutical Gel. Current Pharma Research. 2018;9(1):2576-88.

. Basha BN, Prakasam K, Goli D. Formulation and evaluation of gel containing fluconazole-antifungal agent. Int J Drug Dev Res. 2011;3(4):119-27.

. Tanwar Y, Jain AK. Formulation and evaluation of topical diclofenac sodium gel using different gelling agent. Asian Journal of Pharmaceutical Research and Health Care. 2012;4(1).

. Helal DA, Attia D, Abdel-Halim SA, El-Nabarawi MA. Formulation and evaluation of fluconazole topical gel. 2012.

. Das S, Samanta A, Bose A. Design, development and evaluation of Fluconazole topical gel. Asian Journal of Pharmaceutical and Clinical Research. 2015;8(2):132-5.

Downloads

Published

2021-02-14

How to Cite

B.Pharm, A. G., B.Pharm, S. M. ., M.Pharm, S. S. ., M.Pharm , S. P. ., B.Pharma , N. T. ., Shrestha, D. J. R. ., & M.Pharm , M. B. L. G. . (2021). Formulation & Evaluation of Fluconazole Gel for Topical Drug Delivery System. American Scientific Research Journal for Engineering, Technology, and Sciences, 76(1), 124–137. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/6605

Issue

Vol. 76 No. 1 (2021)

Section

Articles

License

Authors who submit papers with this journal agree to the following terms.