The Chemistry of Khat and Adverse Effect of Khat Chewing

Authors

  • Alemayehu Gashawa
  • Tewodros Getachew

Keywords:

Khat, Phenylpentenylamines, Phenylpropylamines, Gastrointestinal tract

Abstract

The leaves of khat shrub have a stimulating effect, and the chewing of this material has been practiced for many centuries in certain areas of East Africa and Arabian Peninsula. Khat is widely consumed among the youth of Ethiopia; especially among high school, College and University students as well as drivers. The active ingredient of khat responsible for its psycho stimulant effect is an alkaloid chemical known as cathinone, which is structurally and chemically similar to d-amphetamine, and cathine, a milder form of cathinone. Cathinone is a highly potent stimulant, which produces central nervous system stimulation analogous to the effect of amphetamine. The major effects of khat chewing include those on the gastro-intestinal system and on the nervous system. The negative effects of khat also include increased blood pressure, tachycardia, insomnia, anorexia, constipation, urine retention, irritability and impaired sexual potency in men. This review highlights the chemistry of khat, the health, social and economical aspects of khat chewing particularly in Ethiopia. 

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Published

2014-07-21

How to Cite

Gashawa, A., & Getachew, T. (2014). The Chemistry of Khat and Adverse Effect of Khat Chewing. American Scientific Research Journal for Engineering, Technology, and Sciences, 9(1), 35–46. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/633