Effectiveness Test on Centella asiatica Extract on Increasing Elasticity Level on Male Mus Musculus

  • Celvin Angkasa Master of Biomedical Science, Faculty of Medicine, Prima Indonesia University, Medan, North Sumatera, Indonesia
  • Alexander Angkasa Master of Biomedical Science, Faculty of Medicine, Prima Indonesia University, Medan, North Sumatera, Indonesia
  • I Nyoman Ehrich Lister Department of Physiology, Faculty of Medicine, Prima Indonesia University, Medan, North Sumatera, Indonesia
  • Ermi Girsang Faculty of Public Health, Prima Indonesia University, Medan, Indonesia
  • Edy Fachrial Laboratory of Biomoleculer, Faculty of Medicine, Prima Indonesia University, Medan, Indonesia
Keywords: Centella asiatic; Anti-aging; Elasticity.

Abstract

Gotu kola (Centella asiatica), is one of the plants with a potential development in dermatocosmetology, because it contains triterpenoid compounds, asiaticoside, madecassoside, flavonoids, efficacious as an antioxidant and prevent skin premature aging. The aim of this study was to compare the effectiveness of anti-aging extract of Centella asiatica to increase elasticity levels. Phytochemical test results of extracts contain alkaloids, tannins, triterpenoid, flavonoids, glycosides. The results showed that the research data were abnormally distributed (p <0.05), the average highest measurement of skin elasticity levels was found in the 10% extraction treatment group. The difference in the average measurement of significant elasticity levels at weeks 2, 3, and 4 were p <0.005 (p0,045; p0,008; p0,009). The difference in average elasticity level will increase significantly (p <0.005) in line with the length of time spent. Cream with 10% of Centella asiatica  extract showed an increase in skin elasticity levels by 40.58%. The multiple linear regression test, the greatest Pearson correlation value at week 4 on all measurements was found in comparison with week 3, elasticity levels (94.2% p0,000) and the results of the correlation value increased significantly with the addition of treatment time (p <0.005). In conclusion, the results of this study indicate the administration of Centella asiatica extract increased the average of elasticity level compared to the control group, positively correlated with the increase of the duration and the quantity of Centella asiatica extract were given.

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Published
2019-08-10
Section
Articles