Antimicrobial Activity of Lemon (Citrus limon) Peel Extract Against Escherichia coli

Alhoi Hendry Henderson, Edy Fachrial, I. Nyoman Ehrich Lister


In developing country herbal medicine used widely to treat infectious disease. The Citrus limon peel rich in nutrient such as flavonoid and essential oil that can used for antimicrobial and anticancer activity. The Citrus limon peel extracted with ethanol 96% using maceration extraction and then dissolved with DMSO. The antimicrobial activity tested against Escherichia coli using disc diffusion assay. The present study shows the antimicrobial activity of the ethanolic extract of the Citrus limon peel of 25%, 50%, 75% and 100% had a strong antimicrobial activity against Escherichia coli were 15,03 mm; 16,17 mm; 15,83 mm; 18,77mm of the average inhibition zone, respectively. The essential oil can disrupt the bacterial membrane and damage the lipids and proteins layer. The flavonoid can inhibit specific enzymes and scavenge free radical. It concluded that lemon (Citrus limon) peel extract have a high potential on antimicrobial activity against the Escherichia coli.


Citrus limon peel; Escherichia coli; antimicrobial.

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