Preparation, Characterization of Mixed-Ligand Complexes for Some Divalent Transition Metal Ions Involving Biologically Important Bidentate Ligands

Kamal Rashid Hsejan Al- Jorani

Abstract


This paper describes the synthesis, characterization of mixed ligand complexes. The reaction of benzene-1,2-diamine(o-phenylenediamine) derivatives with anthranilic acid (Ant) yield 2-(1H-benzimidazol-2-yl)aniline derivatives (BIAD) as (primary ligands) in Effective and appropriate solvent, which confirmed by FT-IR, Elemental analyses (C. H. N, O) and 1H NMR spectral. These ligands coordinated with some transition metal ions (CoII ,NiII, CuII, ZnII ) and anthranilic acid as (secondary ligand) at the (1 : 1 : 1) ratio of the components to yielded a mixed-ligand complexes. All complexes have been studied by IR spectra, 1H NMR, Elemental analyses (C. H. N. O), atomic absorption, molar conductivity and magnetic moment. Ligands produce chelates with (1;1;1) (metal; ligands; ligand) interactive elements. From all results was suggested that octahedral geometry to complexes and have the formulae [M(BIAD)(Ant)(H2O)2]2- where M = Co(II), Ni(II), Cu(II) and Zn(II).


Keywords


Mixed-Ligand; anthranilic acid; BIAD; Benzimidazole.

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References


. Gravatt GL Baguley, Bc Wilson. “Synthesis and antitumor activity of DNA minor groove-targeted aniline mustard analogues of pibenzimol”. J.Med.Chem 1994; 37: 4338. http://dx.doi.org/10.1021/jm00051a010

. M. Gabaa, P. Gabaa, D. Uppala, N. Dhingrac, M. S. Bahiad, O. Silakarid, C. Mohan,"Benzimidazole derivatives'': search for GI-friendly anti-inflammatory analgesic agents,Acta. Pharm. Sin B. 5 (2015) 337-342.

. S. A. H. El-Feky, Z. K. A. El-Samii, N. A. Osman, J. Lashine, M. A. Kamel, H. K. Thabet, “Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II”, Bioorg. Chem. 58 (2015)104-116.

. R. S. Kankate a, P. S. Gide, D. P. Belsare, “Design, synthesis and antifungal evaluation of novel benzimidazole tertiary amine type of fluconazole analogues”, Arabian J. Chem. (2015) http://dx.doi.org/10.1016/j.arabjc.2015.02.002.

. C. W. Evans, C. Atkins, A. Pathak, B. E. Gilbert, J. W. Noah, "Benzimidazole analogs inhibit respiratory syncytial virus G protein function'', Antiviral. Res. 121 (2015) 31-38.

. M. C. Sharma, S. Sharma, N. K. Sahu, D. V. Kohli, ''3D QSAR kNN-MFA studies on 6-substituted benzimidazoles derivatives as nonpeptide angiotensin II receptor antagonists'': A rational approach to Anti-hypertensive agents, J. Saudi. Chem. Soc. 17 (2013) 167-176.

. C. G. Opez, F. V. Albores, V. G. Prieto, M. Ruocco, M. Lorito, ''Changes in Trichoderma asperellum enzyme expression during parasitism of the cotton root rot pathogen Phymatotrichopsis omnivore", Fungal. Biol. 119 (2015) 264-273.

. Z. Zhang, K. K. Ojo, S. M. Johnson, E. T. Larson, P. H. J. A. Geiger, A. C. Gonzalez, A. C.White, M. Parsons, E. A. Merritt, D. J. Maly, C. L. M. J. Verlinde, W. C. V. Voorhis, E. Fan, ''Benzoylbenzimidazole based selective inhibitors targeting cryptosporidium parvum and toxoplasma gondii calcium-dependent protein kinase-1", Bioorg. Med. Chem. Lett. 22 (2012) 5264-5267.

. K. S INDALKAR, C. K KHATRI and G. U CHATURBHUJ, ''Rapid, efficient and eco-friendly procedure for the synthesis of quinoxalines under solvent-free conditions using sulfated polyborate as a recyclable catalyst", J. Chem. Sci. Vol. 129, No. 2, February 2017, pp. 141–148.

. P. Li, Y. Zhu, S. He, J.Fan, Q. Hu, and Y. Cao, ''Development and Validation of a High-Performance Liquid Chromatography Method for the Determination of Diacetyl in Beer Using 4-Nitro-o-phenylenediamine as the Derivatization Reagent". dx.doi.org/10.1021/jf3007163 | J. Agric. Food Chem. 2012, 60, 3013−3019.

. Poonia NS,Truter MR ,J Chem Soc Dalton Trans 16: 1791, (1972).

. T. Narsinghani, R. Sharma, ''Synthesis, anti-inflammatory activities and docking studies of amide derivatives of meclofenamic acid". Chem. Pap. (2016).

. R. S. Azarudeen, A. R. Burkanudeen, ''Synthesis, Spectral, Morphology, Thermal Degradation Kinetics and Antibacterial Studies of Terpolymer Metal Complexes". J Inorg Organomet Polym (2012) 22:791–806.

. J. Lu, J. Guo, W. Sang, H. Guo, ''Mixed-ligand oxovanadium complexes incorporating Schiff base ligands: synthesis, DNA interactions, and cytotoxicities". Transition Met Chem (2013) 38:481–488

. T.G. Ros, M.K. van der Lee, A.J. van Dillen, J.W. Geus, D.C. Koningsberger. ''Rhodium complexes with N-phenyl anthranilic acid ligands as catalysts for hydrogenation". Journal of Molecular Catalysis A: Chemical 186 (2002) 13–24

. P. C.R. Soares-Santos, R. A. S. Ferreira, T. Trindade, L. D. Carlos, H. I.S. Nogueira. ''Terbium(III) complexes of 2-aminonicotinic, thiosalicylic and anthranilic acids: synthesis and photoluminescence properties". Journal of Alloys and Compounds 451 (2008) 575–577

. E. C. Brien, E. Farkas, M. J. Gil, D. Fitzgerald, A. Castineras, K. B. Nolan. ''Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]ClPH2Sha, a model for a peroxidaseinhibitor Complex". Journal of Inorganic Biochemistry 79 (2000) 47–51

. A. García-Raso, J. J. Fiol, B. Adrover, P. Tauler, A Pons, I. Mata, ''E. Espinosa and E. Molins", Polyhedron, 22, 3255 (2003).

. S. Gaubert, M. Bouchaut, V. Brumas, and G. Berthon, ''Copper--ligand interactions and the physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copper-driven Fenton chemistry in vitro.". Free Radic Res. , 2000 May;32(5):451-61.

. M. k. Hassan. ''Dioxouranium(VI) mixed ligand complexes containing o-substituted benzoic zcid and α-amino acids''. Transition Met. Chem, 16, 618-621 (1991).

. D.A.Skooge;"Fundamentals of Analytical Chem."5thEd.,New- York, 87, p:24411,1988.)

. F. Kratz, B. Nuber, J. Weib and B.K. ''Keppler. Synth. Inorg. Met". Org. Chem. 21, 1601-1613 (1991).

. Cathrine A. Southern† and Donald H. Levy. ''Electronic and Infrared Spectroscopy of Anthranilic Acid in a Supersonic Jet". J. Phys. Chem. A 2003, 107, 4032-4040

. W. brzyska, Z. rzaczynska "Complexes of Heavy Lanthanides With o-Aminobenzoic Acid" Monatshefte fur Chemie 119, 147-156 (1988).

. M. Rrichenbacher and J. Popp. ''challenges in molecular structure determination", P.108-109, 2012.


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