Comparative Efficacy of Acacia Honey and Aloe Vera Gel on Healing of Induced Lacerated Wound in Rabbits

Arsalan Khan, Khurram Ashfaq, Jalal ud Din, Amjad Ali, Ambrina Tariq, Sheeraz Ghani, Najeeb Ullah, Yasir Sulaman, Muhammad Farooq Ahmad

Abstract


Wound is an injury as a result of trauma and break in the integrity of skin. For restoration of the continuity of skin, the disrupted skin and anatomical continuity should be managed appropriately for normal and efficient wound healing. Therefore, the study was designed to analyze the comparative efficacy of Acacia honey and Aloe vera gel on lacerated wound induced in rabbits. For this purpose, a total of 18 healthy male rabbits were selected and divided randomly into three groups i.e. Group A, B and C. Lacerated wounds were induced in these rabbits aseptically by sharp blunt scissor, post anesthetization with ketamine hydrochloride @40mg/kg body weight. Rabbits of group A were treated with commercially available Acacia honey applied topically twice daily, group B rabbits were treated with Aloe vera gel topically twice daily while group C served as control and treated with standard treatment pyodine. The efficacy of the treatments was evaluated in terms of wound contraction, wound healing, and tensile strength. Wound contraction was found higher in group A and B compared to group C and increased at day 10. Significant tensile strength was recorded in honey treated group. Healing time of group A and B was lower and statistically significant than the control. 


Keywords


Acacia honey; Aloe vera; lacerated wound; tensile strength; wound healing.

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References


Barreto, R.S.S, R.L.C. Albuquerque-Junior, A.A.S. Araujo, J.R.G.S. Almeida, M.R.V. Santos, A.S. Barreto, et al. 2014. A systematic review of the wound-healing effects of monoterpenes and iridoid derivatives. Molecules, 19: 846-862.

Chan, E.W.C., Y.Y. Lim, L.F. Wong, F.S. Lianto, S.K. Wong, K.K. Lim, et al. 2008. Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species. Food Chem., 109: 477–483.

Sumitra, M., P. Manikandana, L. Suguna, 2005. Efficacy of Buteamono sperma on dermal wound healing in rats. Int. J. Biochem. Cell Biol., 37: 566–573.

Ayyanar, M. and S. Ignacimuthu, 2009. Herbal medicines for wound healing among tribal people inSouthern India: Ethnobotanical and Scientific evidences. Int. J. Appl. Res. Nat. Prod., 2: 29–42.

Rawat, S., R. Singh, P. Thakur, S. Kaur, A. Semwal, 2012. Wound healing agents from medicinal plants: A review. Asian Pac. J. Trop. Biomed., 2: 1910–1917.

Kumara, P.D., G.L. Jayawardane and A.P. Aluwihare, 2001. Complete colonic duplication in an infant. Ceylon Med. J., 46: 69-70.

Mundo, M.A., O.I. Padilla-Zakour and R.W. Worobo, 2004. Growth inhibition of food-borne pathogens and food spoilage organisms by select raw honeys. Int. J. Food Microbiol., 97: 1–8.

Lusby, P.E., A. Coombes and J.M. Wilkinson, 2002. Honey: A potent agent for wound healing. J. Wound Ostomy Conti. Nurs., 29: 295-300.

Molan, P.C., 2002. Re-introducing honey in the management of wounds and ulcers theory and practice. Ostomy Wound Manag., 48: 28-40.

Ahmed, M. and F. Hussain, 2013. Chemical composition and biochemical activity of Aloe vera (Aloe barbadensis miller) leaves. Int. J. Chem. Biochem. Sci., 3: 29-33.

Ghosh, A.K., M. Banerjeea, T.K. Mandal, A. Mishra, M.K. Bhowmik, 2011. A study on analgesic efficacy and adverse effects of Aloe vera in wistar rats. Pharmacologyonline, 1: 1098-1108.

Kundu, S., T.K. Biswas, P. Das, S. Kumar and D. Kumar, 2005. Turmeric (Curcuma longa) rhizome paste and honey show similar wound healing potential: A preclinical study inrabbits. Int. J. Low. Extrem. Wounds, 4: 205.

Ali, A.M., H. Sohanaki, M. Khaniki, M.A. Mohaghgheghi, G. Ghmami and M. Mosavi, 2011. The effect of Teucrium Polium honey on the wound healing and tensile. Iran. J. Basic Med. Sci., 14: 499-505.

Nisbet, H.O., C. Nisbet, M. Yarim, A. Guler and A. Ozak, 2010. Effects of three types of honey on cutaneous wound healing wounds. Orig. Res., 22: 275–283.

Iftikhar, F., M. Arshad, F. Rasheed, D. Amraiz, P. Anwar and M. Gulfraz, 2010. Effects of Acacia honey on wound healing in various rat models. Phytother. Res., 24: 583–586.

Okeniyi, J.A.O., O.O. Olubanjo, O. Tinuadea and A. Oyeku, 2010. Comparison of healing of incised abscess wounds with honey and eusol dressing. J. Altern. Complement Med., 11: 511–513.


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