Crohn's Disease: A Comparative Study on the Noninvasive Diagnostic Methods for Small Bowel Disease

Oluwaseyi Joy Alao, Akinwale Folarin Ogunlade, Chidambra Dhariwal Halari, Moheem Masumali Halari


The non-invasive methods used in the diagnosis of small bowel disease includes; Capsule Endoscopy, Double Balloon Enteroscopy, Single Bowel Enteroscopy, Computed Tomographic Enterography, Magnetic Enterography, Small Bowel Follow Through and Small Intestine Contrast Ultrasonography. These techniques have been useful in detection of suspected and established Crohn’s disease, mucosal lesions, extraluminal extensions, fistula, abscesses, fistulas etc. The objective of this research was to compare the non-invasive techniques used for diagnosis of Crohn’s disease with the aim of proposing the most preferred. MEDLINE, EMBASE and Cochrane databases were searched for studies involving non-invasive diagnostic method for CD. Different diagnostic techniques were analyzed and compared for parameter such as specificity, sensitivity and detection of complication. It was concluded that Small Intestine Contrast Ultrasonography (SICUS) was the most preferred technique with the sensitivity of 97.5% and specificity of 100%. In addition, SICUS showed high accuracy for detection of complications in the small intestine in comparison to other diagnostic modalities. 


Crohn’s disease; Diagnostic methods; Small bowel disease; Small intestine contrast ultrasonography; Capsule endoscopy; Double balloon enteroscopy; Single bowel enteroscopy; Computed tomographic enterography; Magnetic enterography; Small bowel follow throu

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