Osteoradionecrosis of the Jaws after Radiotherapy Treatment in Head and Neck Area
Keywords:
osteoradionecrosis, radiotherapy, antibiotics, oncological disease, wound healing, oral surgery, oral medicineAbstract
Although it can be stated that the incidence of osteoradionecrosis of the jaws (ORNJ) in the last reported period decreases, the therapy of this diagnosis has a considerably more complicated continuance as with bisphosphonates osteonecrosis (BON). Oral findings are extensive, not only alveolar bones of jaws are affected by radiation, but also oral mucosa and salivary glands, resulting to a significant mucositis and xerostomia. Research in dental and oral surgery often involves materials and procedures which are capable of improving clinical outcomes in terms of percentages of success. The goal of this research was to find a treatment approach which could reduce bleeding, promote effective bone regeneration and rapid soft-tissue healing by employing resources which are easy to use at a modest cost. Patients in our study were divided into three categories: patients with newly diagnosed cancer waiting for treatment, patients after radiotherapy without signs of osteonecrosis and patients with fully developed osteoradionecrosis of jaws.
References
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[23] M. Burke., M. Fenlon.: “Osteradionecrosis – a review of prevention and management. “ Journal of Disability and Oral Health (2010) 11/1 03/09
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[26] A. Albanese., ME. Licata., B. Polizzi., G. Campisi.: “Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. “ Immun Ageing. 2013 Jun 13;10(1):23. doi: 10.1186/1742-4933-10-23.
[2] A., Gevorgyan., K., Wong., I., Poon., N., Blanas., D.J., Enepekides., K.M., Higgins.: “Osteoradionecrosis of the mandible: a case series at a single institution.“ Journal of Otolaryngology - Head & Neck Surgery 2013, 42:46.
[3] M. Masayuki., H. Shinya., M. Sunaho., T. Osamu., M. Keisuke., S. Toshiyuki., I. Yatsuji., H. Hiroaki.: “4 Gy single fraction palliative radiotherapy for the treatment of painful recurrent soft plate carcinoma by high-dose-rate mold brachytherapy.“ Oral Oncology Extra. Volume 42, Issue 10, November 2006, Pages 305–307.
[4] S. Nabil, N. Samman.: “Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review“. Int J Oral Maxillofac Surg, 40 (2011), pp. 229–243.
[5] DK. Lam, GK. Sándor, HI. Holmes.: “A review of bisphosphonate – associated osteonecrosis of the jaws and its management.“ J Can Dent Assoc. 2007., 73.
[6] WL. Watson., JE. Scarborough.: “Osteoradionecrosis in intraoral cancer. “ Am J Roent 1938, 40. p. 524 – 534.
[7] Kishore, Shetty, Heber Tuf.: “Dental management of the pediatric post radiation therapy—rhabdomyosarcoma patient: Case reports and review of literature. “ Oral Oncology Extra. Volume 41, Issue 9, October 2005, Pages 242–248
[8] R. De Crevoisier, J. Bourhis, C. Domenge, P. Wibault, S. Koscielny, A. Lusinchi, and his colleagues : “Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients. “ J Clin Oncol, 16 (1998), pp. 3556–3562.
[9] WK. Stadelmann,., AG. Digenis., TR. Gordon.: “Physiology and healing Dynamics of chronic cutaneous wounds. “ Am. J. Surg., y. 176, 1998., Suppl. 2A, s. 26 – 38.
[10] UR. Maddireddy., VR. Gogula., UR. Pingali., KM. Lyyapu., S. Avula., R. Priyadarshni.: “Chemotherapy-Induced and/or Radiation Therapy-Induced Oral Mucositis-Complicating the Treatment of Cancer. “ Neoplasia, Volume 6, Issue 5, September–October 2004, Pages 423–431
[11] WG. Payne, and his colleagues : “Long – term outcome study of growth factors – treated pressure ulcers. “ Am. J. Surg., y. 181, 2001, no. 1, p. 81 – 88.
[12] J.J. Mazeron, J. Simon, C. Le Péchoux, and his colleagues : “Effect of dose rate on local control and complications in definitive irradiation of T1-2 squamous cell carcinoma of mobile tongue and floor of mouth with interstitial iridium 192. “ Radiother Oncol, 21 (1991), pp. 39–47.
[13] S. Vratislav., L. Michael., K. Stephan., F. Rainer.: “Interstitial pulsed-dose-rate brachytherapy for head and neck cancer—Single-institution long-term results of 385 patients. “ Brachytherapy, Volume 12, Issue 6, November–December 2013, Pages 521–527.
[14] M. Mehrotra, S. Ruggiero.: “Bisphosphonate complications including osteonecrosis of the jaw. “ Hematology/The Education Program of the American Society of Hematology American Society of Hematology Education Program, 356–60 (2006), p. 515.
[15] S. Delenian,., JL. Lefaix.: “The radiation – induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. “ Radiother Oncol 2004, 73. p. 119 – 131.
[16] B.R. Chrcanovic, P. Reher, A.A. Sousa, M. Harris.: “Osteoradionecrosis of the jaws—a current overview—part 2: dental management and therapeutic options for treatment. “ Oral Maxillofac Surg, 14 (2010), pp. 81–95.
[17] R. Marx.: “Osteoradionecrosis: a new concept of its pathophysiology. “ J Oral Maxillofac Surg 1983, 41. p. 283 – 288.
[18] A. Kitamura., Y. Kawai.: “Basic investigation of the laminated alginate impression technique: Setting time,permanent deformation, elastic deformation, consistency, and tensile bond strength tests. “ Journal of Prosthodontic Research Vol. 59, Issue 1, January 2015, Pages 49–54.
[19] N. Matsumoto, F. Kawano, T. Ichikawa.: “Impression techniques of complete denture based on border seal.“ Nippon Dental Rev,546 (1988), pp. 109–120.
[20] P.C. Owen.: “Guidelines for a minimum acceptable protocol for the construction of complete dentures. “ Int J Prosthodont, 19 (2006), pp. 467–474.
[21] MJ. Shaw., NDK. Kumar., M. Duggal., J. Fiske., D. Lewis., T. Kinsella., T. Nisbett.: “Clinical Guidelines. The oral management of oncology patients requiring radiotherapy : chemotherapy : bone marrow transplantation. “ The Dental Faculty of the Royal College of Surgeons of England, London 1999.
[22] F. Sulaiman., JM. Huryn, IM. Zlotolow.: “Dental extractions in the irradiated head and neck patient: A retrospective analysis of Memorial Sloan-Kettering Cancer Centre protocols, criteria and end results. “ J Oral Maxillofac Surg 2003; 61: 1123-1131.
[23] M. Burke., M. Fenlon.: “Osteradionecrosis – a review of prevention and management. “ Journal of Disability and Oral Health (2010) 11/1 03/09
[24] AN. Kanatas., SN. Rogers., MV. Martin.: “A survey of antibiotic prescribing by maxillofacial consultants for dental extractions following radiotherapy to the oral cavity. “ Br Dent J 2002; 192: 157-160.
[25] DJ. Alexandra., P. Melanie., VN. Anna., C. Naved., U. Matthias., WM. Marc., KH. Klaus., D. Jürgen.: “Re-irradiation of adenoid cystic carcinoma: Analysis and evaluation of outcome in 52 consecutive patients treated with raster-scanned carbon ion therapy. “ Radiotherapy and Oncology. Volume 114, Issue 2, February 2015, Pages 182–188.
[26] A. Albanese., ME. Licata., B. Polizzi., G. Campisi.: “Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. “ Immun Ageing. 2013 Jun 13;10(1):23. doi: 10.1186/1742-4933-10-23.
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Published
2015-08-11
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Riznic, M., & Göbl, J. (2015). Osteoradionecrosis of the Jaws after Radiotherapy Treatment in Head and Neck Area. American Scientific Research Journal for Engineering, Technology, and Sciences, 12(1), 212–221. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/880
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