Symptoms and Laboratory Findings of Patients Diagnosed with Typhoid Fever at the Time of Admission into the Health Service Facility
Typhoid fever is a systemic infection caused by the Gram-negative bacilus Salmonella typhii. Typhoid fever spreads through food or drink contaminated with S.typhii. Diagnosis is established through anamnesis, physical examination and laboratory assessment. Aims of this study are to identify the frequent symptoms and the results of laboratory assessment of patients diagnosed with typhoid fever. Medical records of adult, male and female patients diagnosed with typhoid fever during the year 2016 and with Immunoglobuline-G anti Salmonella Test Score 4 - 6, enrolled in this study. Medical records used as a source of information of complaints, vital signs, and clinical laboratory results at the time of admission. Some of the most frequent complaints were fever, folowed by nausea, headache, vomit, diarrhea or loose stool. Fourteen (82.4% of total) patients presented with fever, fever with relative bradycardia covered 12 (70.6% of total patients). Immunoglobuline-G (Ig-G) anti Salmonella test score 4-5 (positive indication) were more frequent than score ³ 6 (strong indication of typhoid fever). Leucocyte count <5000/uL covered 29.4% of patient. Thrombocyte count <100.000 /uL covered 17.6%. The most frequent complaints at the time of admission were fever, followed by nausea, headache, vomit, diarrhea or loose stool. This study found relative bradycardia and bicytopenia, and positive indication of Ig-G anti Salmonella Test Score were more frequent than strong indication of typhoid fever.
World Health Organization. "Background document : The diagnosis, treatment and prevention of typhoid fever. In: Communicable Disease Surveillance and Response Vaccines and Biologicals" [Internet]: www.who.int/vaccines-documents/ [ Mar 16, 2018].
J. A. Crump, S. P. Luby, E. D. Mintz. "The global burden of typhoid fever". Bull World Health Organ. vol. 82, pp. 346 - 53, 2004.
V. Mogasale, B. Maskery, R. L. Ochiai, J. S. Lee, V V Mogasale., Ramani E, et al. "Burden of typhoid fever in low-income and middle-income countries: A systematic, literature-based update with risk-factor adjustment". The Lancet Global Health.; vol. 2, pp. e570 - 80, 2014.
N. Q. Chanh, P. Everest, T. T. Khoa, D. House, S. Murch, C. Parry, et al. "A Clinical, Microbiological, and Pathological Study of Intestinal Perforation Associated with Typhoid Fever". Clinical Infectious Diseases. vol. 39, pp. 61 - 7, 2004.
L. Østergaard, B. Huniche, P. L. Andersen. "Relative bradycardia in infectious diseases". Journal of Infection. vol. 33, pp. 185 - 91, 1996.
H. T. Pohan. "Clinical and laboratory manifestations of typhoid fever at Persahabatan Hospital, Jakarta". Acta Medica Indonesiana. vol. 36, pp. 78 - 83, 2004.
A. Vollaard, S. Ali, H. van Asten, S. Widjaja, S. Visser, L. Visser, et al. "Risk Factors for Typhoid and Paratyphoid Fever in Jakarta, Indonesia". JAMA. vol. 291, pp. 2607 - 15, 2004.
M. Subhan, W. Sadiq. "Case of Enteric Fever with Bicytopenia". Cureus. vol. 9, pp. 10-2, 2017.
U. K. Paul, A. Bandyopadhyay. "Typhoid fever : a review". International Journal of Advances in Medicine. vol. 4, pp. 300- 6, 2017.
M. H. Gasem, H. L. Smits, M. G. A. Goris, M. V. Dolmans. "Evaluation of a simple and rapid dipstick assay for the diagnosis of typhoid fever in Indonesia". Journal of Medical Microbiology. vol.51, pp. 173 - 7, 2002.
L. Wijedoru, S. Mallett, C. M. Parry. "Rapid Diagnostic Tests for Typhoid and Paratyphoid (Enteric) Fever". Cochrane Database System Review.vol.5: 1-149, 2017..
A. Tarupiwa, S. Tapera, S. Mtapuri-Zinyowera, P. Gumbo, V. Ruhanya, M. Gudza-Mugabe, et al. "Evaluation of TUBEX-TF and onsite typhoid IgG/IgM combo rapid tests to detect Salmonella enterica serovar typhi infection during a typhoid outbreak in Harare, Zimbabwe". BMC Research Notes. vol.8, pp. 1-4, 2015.
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