Quality of Life in a Sample of Patients with Major Depressive Disorder in Bahrain: Case-Control Study

Mohamed A. Serageldien, Waiel Alani, Wafaa Al Motawa, Haya Al Noaimi, Zain Buallay, Khaled Al Jalahma


Studies have placed the lifetime prevalence of major depressive disorder (MDD) is about 15%. The World Health Organization Global Burden of Disease Survey suggested that MDD would become the second leading cause of disability by the year 2020. Most of the patients ranging between 18-45 years old (experiencing MDD) will constitutes an economic and social burden on the families and the country as a whole as this is expected to be the age of active productivity and participation in the national development. Our study will throw some light on the quality of life in MDD patients to offer better understanding of psychosocial impact of MDD that allow us to develop new better treatment for MDD. The objectives of this study is to assess the quality of life of outpatients with depression, to find out whether the quality of life impairment is specific for MDD or whether they are general phenomena and to correlate between the severity of MDD and quality of life domains. 30 patients (13 male and 17 female) diagnosed with Major Depressive Disorder by the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) that visited the psychiatric clinic at the Bahrain Defense Forces hospital participated in the study answering a study questionnaire that included the questionnaire of socio-demographic characteristics, 17-item Hamilton Depression Rating Scale (HAMD-17), General Health Questionnaire (GHQ), Short-Form 36 Health Survey Version 2 (SF-36) for quality of life evaluation. In our study; it was found that the patients were of comparable education level to the controls showing a high statistical significant difference. Also, there were statistical significance regarding the type of employment; 16(53.3%) unskilled, 4(13.3%) semiskilled, 10(33.3%) skilled. The correlation between severity of depression and Qol domains has shown statistical significance regarding: RE (0.000), VT (0.005), MH (0.038), SF (0,001), BP (0.031). Moreover, all SF36 subscales were significantly different between both groups. This study shows that depression significantly affects the QOL of patients. The overall subjective QOL domains of the patients were shown to be poorer when compared to that of the control population.

The study also revealed that patients who suffer from depression experience marked reduction in functioning when compared with non-depressed 


Major depressive disorder; SF-36; Qol.

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