Spasmolytic Effects of Aqueous Extract of Sterculia setigera Delile on Isolated Rat Trachea

Authors

  • Judith F. Ahounou Aïkpe Laboratoire de Pharmacognosie et des Huiles Essentielles, Faculté des Sciences de la Santé, Faculté des Sciences et Techniques, Université d’Abomey Calavi 01 BP 188 Cotonou Bénin. Laboratoire de Physiologie de l’Effort, Institut National de la Jeunesse de l’Education Physique et du Sport, Université d’Abomey Calavi. 01 BP 169 Porto-Novo Bénin.
  • André Hamadou Laboratoire de Physiologie de l’Effort, Institut National de la Jeunesse de l’Education Physique et du Sport, Université d’Abomey Calavi. 01 BP 169 Porto-Novo Bénin.
  • Géoffroy Ouedraogo Institut de Recherche en Science de la Santé, Département Médecine et Pharmacopée Traditionnelles/Pharmacie, 03BP7192 Ouagadougou 03, Burkina Faso
  • Sylvin Ouedraogo Institut de Recherche en Science de la Santé, Département Médecine et Pharmacopée Traditionnelles/Pharmacie, 03BP7192 Ouagadougou 03, Burkina Faso
  • Joachim D. Gbenou Laboratoire de Pharmacognosie et des Huiles Essentielles, Faculté des Sciences de la Santé, Faculté des Sciences et Techniques, Université d’Abomey Calavi 01 BP 188 Cotonou Bénin. Laboratory of Pharmacognosy and Essential Oils, Faculty of Sciences and Techniques, University of Abomey Calavi, 01 BP 918, ISBA Cotonou, Republic of Benin, Tel : 00 (229) 64 11 62 22, 97 53 35 51
  • Pierre H. Dansou Laboratoire de Physiologie de l’Effort, Institut National de la Jeunesse de l’Education Physique et du Sport, Université d’Abomey Calavi. 01 BP 169 Porto-Novo Bénin.

Keywords:

Sterculia setigera, bronchodilatory, spasmolytic, Rat trachea.

Abstract

The spasmolytic properties of aqueous extract of Sterculia setigera was tested on Rat isolated trachea. Inhibition of the contraction was observed in presence of the aqueous extract (EC50 = 0.91mg/mL ± 0.02) after a pre contraction of the trachea by acetylcholine (10-5M). In the presence of propranolol (10-6M), the spasmolytic activity of the extract was inhibited. The EC50 value was 0.46mg/mL ± 0,11. The aqueous extract of Sterculia setigera also inhibited contraction induced by KCl (4.10-2 M) with EC50 value = 1.9mg/mL ± 0.48).  These results clearly show a relaxing effect of aqueous extract of Sterculia setigera on the trachea isolated from rat. This effect involves at least in part ?-adrenergic receptor inhibition.

References

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Published

2017-05-18

How to Cite

Aïkpe, J. F. A., Hamadou, A., Ouedraogo, G., Ouedraogo, S., D. Gbenou, J., & H. Dansou, P. (2017). Spasmolytic Effects of Aqueous Extract of Sterculia setigera Delile on Isolated Rat Trachea. American Scientific Research Journal for Engineering, Technology, and Sciences, 31(1), 301–307. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/2979

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