Synthesis of Diaznylpyrazol Derivatives

Sali Abdelal, Abdullah Gheath, Naowara Alarafi, Ghazala Hasim

Abstract


In our present study 4-methylaniline (1) has been reacted with acetyl acetone(2) in presence of sodium nitrite  and sodium acetate yielded 3-(2-(p-tolyl) hydrazono) pentane-2,4-dione (3) which react with hydrazine hydrate  to give 3,5-dimethyl-4-(p-tolyldiazenyl)-1H-pyrazole (4) and react with 2-chloro-N(substituted phenyl) acetamide(5a-5g) to give (6a-6g). All the synthesized compounds were characterized on the basis of melting point, TLC and NMR spectra.


Keywords


4-substituted aniline; sodium nitrite; sodium acetate; hydrazine hydrate; phenyl hydrazine; 2-chloro- N (substituted phenyl) acetamide; 2-chloro-N(substituted phenyl) acetamide.

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References


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