Synthesis of Diaznylpyrazol Derivatives
In our present study 4-methylaniline (1) has been reacted with acetyl acetone(2) in presence of sodium nitrite and sodium acetate yielded 3-(2-(p-tolyl) hydrazono) pentane-2,4-dione (3) which react with hydrazine hydrate to give 3,5-dimethyl-4-(p-tolyldiazenyl)-1H-pyrazole (4) and react with 2-chloro-N(substituted phenyl) acetamide(5a-5g) to give (6a-6g). All the synthesized compounds were characterized on the basis of melting point, TLC and NMR spectra.
(a) L. Knorr (1883, July). "Ein wirkung von acettessiges ter auf phenyl hydrazine", Beriche Der Deutschen Chemischen Gesellschaft [on-line], 16 (2), pp. 2597-2599. Available: http://onlinelibrary.wiley.com/doi/10.1002/cber.188301602194/abstract;jsessionid=877B9714679A4608CEC5F556DCB69FCF.f03t03
(b) L. Knorr (1884, July). "Ueber die constitution der chinizinderivate ", Beriche Der Deutschen Chemischen Gesellschaft [on-line], 17 (2), pp. 2032-2049. Available: http://onlinelibrary.wiley.com/doi/10.1002/cber.18840170298/full
(c) T. L. Jacobs. “Pyrazoles and related compounds,” in Heterocyclic Compound, vol. 5. R. C. Elderfield, Ed. New York: John Willy & Sons, 1957, pp.45.
(d) S. M. Sakya. "Knorr Pyrazole Synthesis", In Name Reactions in Heterocyclic Chemistry,. J. J. Li,. E. J.;Corey, Eds. Hoboken, New Jersey: John Willy & Sons, 2005, pp.292-300.
V. K. Aggarwal, J. De Vicente, R. V. Bonnert , (2003,May ). " A Novel One-Pot Method for the Preparation of Pyrazoles by 1,3-Dipolar Cycloadditions of Diazo Compounds Generated in Situ". The Journal of Organic Chemistry. 68 (13),pp. 5381-5383.
S. Fustero, A. Simon-Fuentes, J. F. Sanz-Cervera, (2009, July). "Recent advances in the synthesis of pyrazoles. A Review ", Organic Preparations and Procedures International, 41 (4), pp. 253-290.
S. Cacchi, G. Fabrizi, A. Carangio, (1997). "Functionalised pyrazoles through a facile one-pot procedure from N-tosyl-N-propargyl-hydrazine and aryl iodides or vinyl triflates", Synlett. 8, pp. 959-961, (1997).
Vivek, K.K, International Conference on Bioencapsulation, Groningen, Netherlands, 17, 24-26, ( 2009).
] T. Amita, M. Maridula, K. Sushil, (2011,November)."Synthesis, computional study and preliminary pharmacological evaluation of 2-[4-(2-chlorobenzyl/benzoyl) substituted piperazin-1-yl]-N-phenylacetamide: potential anti psychotics". International Journal of Research in Ayurveda and Pharmacy.6 (2), pp. 1822-1824. Available: http://www.ijrap.net/admin/php/uploads/727_pdf.pdf
S. Banerjee, S. Ganguly, K. K. Sen, K. Choowongkomon, S. Seetaha, (2013) "Synthesis, evaluation and binding mode analysis of some novel triazole derivatives as antimicrobials". Journal of Advanced Pharmacy Education & Research , 3, pp. 494-511.
L. Yurttas, Y. Ozkay,; F. Demirci, G. Goger, S.U. Yildirim, U. Abu mohsen, O. Ozturk, Z.A. Kaplancikli, (2014). "Synthesis, anti candidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chain". Turkish Journal of Chemistry 38(5), p.p. 815- 824.
S.K. Mohanty, A. Khuntia, M.S. Harika, S.P. Sarangi, D.J. Susmitha, (2015, February)." Synthesis, characterization and antimicrobial activity of some oxazole and thiazole derivatives" International Journal of Pharmacy and Pharmaceutical Research, 2 (3), pp. 60-66. Available: http://ijppr.humanjournals.com/wp-content/uploads/2015/02/12.Sujit-Kumar-Mohanty-Anuradha-Khuntia-M.-Sai-Harika-Sarada-Prasad-Sarangi-D.-Jenny-Susmitha.pdf
N.R Thakare, A.K. Dhawas, P.S. Ganoskar, P.D. Kale (2012) ,"Synthesis, characterization of some new 3, 5-dimethyl azopyrazoles and its derivatives". Journal of Chemical and Pharmaceutical Research, 4(6), p.p, 3329-3332. Available: http://www.jocpr.com/articles/synthesis-characterization-of-some-new-3-5dimethyl-azopyrazoles-and-its-derivatives.pdf
- There are currently no refbacks.