Haemostatic Properties of Chrysophyllum Caïnito L. (Sapotaceae) in Wistar Rat

Abstract

The measure of certain blood parameters makes it possible to detect certain pathologies such as the hemophilia and leukemia among patients. Indeed, the aggregating and antiaggreganting activity of certain substances are known. It is a question in this work of checking the effect of the aqueous extract of Chrysophyllum cainito (AECc) on blood. It is a comparative study between AECc and two products of synthesis known for purpose which are the dicynone and the aspirin in vivo in the rats wistar specie Rattus norvegicus. The time of bleeding (TB), the number of blood plates, the red blood corpuscle rate, of hemoglobin, the hematocrit and the sedimentation test (TS) were evaluated. During the first week, the evolution of the time of bleeding (TB) is not significant for all the animals. The second week and until the end of the treatment, the TB drops for the animals treated with EACc in an amount-dependant way. Thus the fall is of 4% for the amounts of 300 mg/kg b.w, 17.4% for the amounts of 500 mg/kg b.w and 30.43% for the amounts of 1000 mg/kg b.w at the end of the treatment. In the animals treated with the dicynone, the fall reaches 41.55% at the end of the thirty days of treatment. On the other hand, in the rats treated with the aspirin, the TB increases as from the second week and reached the rise of 17.40% at the end of the thirty days. On the blood plates, AECc varies their number of manner proportions dependant as of the first week on treatment. The number of blood plates increases by 07.69% and 15.38% for the amount of AECc of 300 mg/kg b.w, 15th and 30th day. The amount of 500 mg/kg b.w of AECc makes increase the number of plates of 09.89%, 21.97%, and 25.16%, respectively 5th, 15th and 30th day.

The concentration of AECc of 1000 mg/kg b.w involves an increase in the plates of 22.31%, 27.36% and 33.07%, respectively with 5th, 15th and 30th day of treatment. The dicynone is managed with the rats with the amount of 500 mg/kg b.w the number of blood plates passes thus from 910±85.83 to 915±88.0, 918±87.0 then 920±92.0; 5th, 15th and 30th days of treatment is 0.55%, 0.88% and 1.09%. This variation is nonsignificant. On the other hand the aspirin managed with the rats with the amount of 500 mg/kg b.w cause a drop in the number of blood plates as of the 5th days with 900±88.2 then with 889±82.2 15th and 750±80.6 the 30th. These drops successive represent rates by -1%,-2.30% and -17.58%. The other factors such as the number of red blood corpuscles the rate of hemoglobin, the hematocrit and also the sedimentation test do not vary significantly before and during the treatment.