Synthesis, Characterization, Antibacterial, Antifungal and Irritant Activities of Organometalic(ll) Complexes of O-Nitro N,N-Dimethylbenzylamine Derivatives

Authors

  • Iram Khan Institute of Chemistry, University of Punjab,lahore.Pakistan ,54000.
  • Zaid Mahmood Institute of Chemistry ,University of Punjab,Lahore.
  • Maham Naz Institute of Chemistry, Government college ,Lahore.
  • Tariq Mehmood Butt butt Institute of Chemistry ,University of Punjab,Lahore.

Keywords:

Bidenate Ligand, Transition Metal complexes, Antimicrobial activity, Disc diffusion method, Spectral studies, Irritant activity.

Abstract

A series of Transition metal  complexes have been  synthesized by reacting with newly prepared  biological active Schiff base ligand .The ligand was prepared by reacting N-bromosuccinimide with O-nitro toluene and reflux for 8hours ,resulting mixture was filtered ,filtrate was o-nitro benzyl bromide which on reaction with dimethyl ammine produce o-nitro N,N-dimethylbenzylamine and characterized by elemental analysis, molar conductivity ,thermal analysis ,X-ray diffraction,IR,UV-Vis spectroscopy and mass spectra. Analytical data confirms the ratio between metal and ligand that is 1:2with octahedral geometry. The IRspectra suggests that ligand behaves as basic bidenate ligand. Molar conductance values suggests non electrolytic nature of metal complexes ,thermal behavior shows more ordered activated state in complex form.

Antibacterial and Anti fungal activities were performed by using new strains of bacteriaBacillussubtilis,Bacilluspumilus,Sarcinalutea,Streptococcusfaecalis,Staphlococcusaureus,Borditellabronchiseptica and fungal strains used were Trichophyton longiusus, Candida albicans, Aspergillus flavis,Microsporum canis, Fusarium solani, Candida glabrata.

The biological activities data showed that complexes of Copper, Chromium, Manganese and zinc exhibited more antimicrobial activities than their parent ligand. Maximum antibacterial activity was exhibited by zinc complex. Moderate antibacterial activity exhibited by copper complex and the minimum antibacterial response was reported with manganese . 

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Published

2016-07-31

How to Cite

Khan, I., Mahmood, Z., Naz, M., & Butt, T. M. (2016). Synthesis, Characterization, Antibacterial, Antifungal and Irritant Activities of Organometalic(ll) Complexes of O-Nitro N,N-Dimethylbenzylamine Derivatives. American Scientific Research Journal for Engineering, Technology, and Sciences, 23(1), 15–28. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/1899

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