Biochemical Assessment of Pregnancy-Related Physiological Changes in Renal Function

Authors

  • Idris Yahaya mohammed Department of Chemical Pathology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria
  • Hajara Damudi bDepartment of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria
  • Balaraba Bello Department of Biochemistry, Modibbo Adama University of Technology, Yola, PMB 2076, Nigeria.
  • Suleiman Isa Yahaya Department of Medical Laboratory Science, Faculty of Health Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria
  • Musa Kurawa Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria
  • Sanni Musa Department of Chemical Pathology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria
  • Zainab Uba Ibrahim Department of Chemical Pathology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria

Keywords:

Renal function, Pregnancy, Urea, Electrolytes, Creatinine.

Abstract

This study was aimed at determining biochemical markers of renal function in pregnant women in Kano State, Nigeria. Urea, electrolytes and creatinine were estimated from 45 pregnant women and 45 non pregnant apparently healthy, age-matched controls.  The result of the study showed significant difference (P<0.01) in urea, creatinine and bicarbonate levels between the pregnant and non- pregnant women but no significant difference (p>0.01) was observed in sodium, potassium and chloride levels between the two groups. Studies within the trimesters showed significant difference (p<0.05) in urea levels between the control group of the 1st and 2nd trimesters.

 Creatinine levels in the 2nd trimester (43.20±12.3) and 3rd trimester (41.40±5.45) were found to be significantly lower (p<0.05) compared to the control group (55.84±16.17). A significant difference in creatinine levels (p<0.05) between the 1st and 2nd and the 1st and 3rd trimesters was also recorded. The mean difference in bicarbonate levels in the 1st (22.33±1.84), 2nd (21.80±1.37) and 3rd(21.73±1.79) trimesters and the -

control group (26.09±2.08) was significantly lower (p<0.05) with no significant difference within the trimesters. There was no significant difference (p>0.05) observed in sodium, potassium and chloride level between the control groups and the trimesters of pregnancy. The result obtained is indicative of normal renal function in the study groups.

Author Biography

Idris Yahaya mohammed, Department of Chemical Pathology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, PMB 3452, Nigeria

Lecturer and Head of Department

Chemical Pathology and Immunology

Bayero University Kano

References

1. C.K. Janet. “Physiology of Pregnancy and Nutrient Metabolism.” Am. J. Clin Nutr.121, 8-25, 2000.
2. R.R. Bailey and G.L. Rolleston. “Kidney length and ureteric dilatation in the pueperium.” Journal of Obstetrics and Gynecology of the British Common Wealth,78, 55-61, 1971.
3. J.M. Davison and W. Dunlop. “Renal hemodynamics and tubular function in normal human pregnancy.”Kidney International,18, 152-161, 1980.
4. A. Faundes, M. Bricola-Filho andJ.L. Pinto e Silva. “Dilatation of the urinary tract during pregnancy:proposalof a curve of maximal caliceal diameter by gestational age.”Am J Obstet Gynecol. 178, 1082–1086, 1978.
5. K.A. Cietak and J.R. Newton. “Serial quantitative maternal nephrosonography in pregnancy.”Br J Radiol. 58, 405–413, 1985.
6. T. Christensen, J.G. Klebe, V. Bertelsen and H.E. Hansen. “Changes in renal volume during normalpregnancy.”Acta Obstet Gynecol Scand. 68,541–543, 1989.
7. C. Roy, C. Saussine and C. Jahn. “Fast imaging MR assessment of ureterohydronephrosis during pregnancy. Magn Reson Imaging.”13, 767–772, 1995.
8. J.M. Davison andM.C. Noble. “Serial changes in 24 hour creatinine clearance during normal menstrual cycles and the first trimester of pregnancy.”Br J Obstet Gynaecol. 88,10–17, 1981.
9. A.B. Chapman, W.T. Abraham and S. Zamudio. “Temporal relationships between hormonal and hemodynamic changes in early human pregnancy.”Kidney Int. 54, 2056–2063, 1998.
10. J.M. Davison andW. Dunlop. “Renal hemodynamics and tubular function normal human pregnancy.”Kidney Int. 18, 152–161, 1980.
11. E. Krutzen, P. Olofsson, S.E. Back andP. Nilsson-Ehle. “Glomerular filtration rate in pregnancy: a study in normal subjects and in patients with hypertension, preeclampsia and diabetes.”Scand J Clin Lab Invest. 52, 387–392, 1992.
12. M.A. Hladunewich, R.A. Lafayette andG.C. Gerby GC. “The dynamics of glomerular filtration in the puerperium.”Am J Physiol Ren Physiol. 286, 496–503, 2004.
13. L. K. Cheung and R. A. Lafayette. “Renal Physiology of Pregnancy.”Adv Chronic Kidney Dis. 20, 209–214, 2013.
14. J. Ochei and A. Kolhatkar(2000). Serum urea estimation: Medical Laboratory Science: Theory And Practice. (6th edition). [Print]. 1(1). Tata McGraw-Hill Education. Pp 114-120.
15. N.Y. Marcel–Decker(1975). Flame Emission and Atomic Absorption Spectroscopy. (Dean, J.A., Rains, T.C., Eds), vols 1, 11, 111.
16. D.D. Van – Slyke. “Notes on portable forms of the monomeric gas apparatus and on certain points in the technique for its use.”J. Biol. Chem 71, 121-26, 1972.
17. O.Schales, and S.S Schales. “A simple and accurate method for the determination of chloride in biological fluids.” J. Biol. Chem. 140, 879-884, 1941.
18. M.Jaffe,“Uber den Niederschlag Welchen Pikrinsale in normalem Harn erzeugt Und Uber eine neue Reaction des Creatinins”. Zeitschrift fur physiologische Cheme, 10(5):391-400, 1886.
*19. B.M Fatima. An Introduction to Biostatistics. (Olumekor, A., Adedokun, O., Eds), second edition. Spectrum Books Limited, Ibadan, Nigeria. 26 – 91. 2008.
20. F.Boag, J.Weerakoon, J.Ginsburg, C.W.Harvard, and P.Dandona. “Serum urea levels in normal pregnancy. “J. Clin. Pathol, 38: 60 – 63. 1985
21. E.A.H Sims, and A.E “Krantz.Serial studies of renal function during pregnancy and puerperium in normal women”. J. Clin. Investigation, 37:1704-1744. 1958.
22. J.M. Davison and M.C.B Noble. “Serial changes in 24 hours creatinine clearance during normal menstrual cycle and the 1st trimester of pregnancy.” Br. J. Obstet. Gynaecol, 88:10-17. 1981.
23. V.E Egwuatu. “Plasma urate, urea and creatinine level during pregnancy and after the puerperium in normal primigravida Nigerians.” Br. J. Obstet.Gynaecol. 90:21-25. 1983.
24. M.D Lindheimer,. and M.D Katz. “Renal Changes during Pregnancy: Their Relevance to Volume Homeostasis.” Clin Obstet Gynecol.2: 345-364. 1975.
25. E.A.E Sims. ” Renal Function in Normal Pregnancy.” Clin. Obstet. Gynecol.11: 461-472. 1968.
26. K.D Edward, H.M Whyte, and E.T Larmie. “Creatinine excretion and body composition.” Clin. Chem. 18: 361-365. 1987. 1989.
*27. D.J Newman, and C.P Prince. Renal Function. In Tietz Fundamental of Clinical Chemistry, 5th Edition. W.B. Saunders Company 34: 698 – 701 and 715 and 422. 2001.
28. M.Monga. “Maternal cardiovascular and renal adaptations to pregnancy”. In: Maternal Fetal Medicine. Principles and practice. (R.K. Creasy, R. Resnik and J.D. Lams Eds). 5th edition. Philadelphia: Saunders. Chapter 8, Pp. 255-262 . 2004
29. R.S Nanra, and P. Kincaid-Smith, Normal Renal Physiology and Changes in Pregnancy.”In:Human Reproductive Physiology. (Shearman, R.P. Ed). Oxford: Alden and Mowbray, Pp. 594-625. 1972.
30. C.A Robb, J.O Davis, J.A Johnsen, E.H Blaine, E.G Schneider, and J.S Banner. “Mechanism Regulating the Renal Excretion of Sodium during Pregnancy.” Clin Invest.49: 871-880. 1970.
*31. F.E Hytten and I..Leitch. The Physiology of Human Pregnancy.2nd edition. Oxford: Blackwell Scientific Publications. Pp. 45,1971.
32. K.L Thornberg, S.L Jacobson, G.D Giraud, and M.J Morton. “Hemodynamic Changes in Pregnancy.” Seminar in Perinatology,24:11. 2000.
33. U. Satyanarayana and U. Chakrapani. Biochemistry 3rd edition. Aniaba Sen, Books and Allied (P) Ltd, 8/1 Chintamoni Das Lane, Kol kata. Pp. 459-483, 411-413. 2010
34. R.L Newman. “Serum Electrolyte in Pregnancy, Parturition and Puerperium” Obstet Gynecol 10: 51-55. 1957.

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Published

2015-12-18

How to Cite

mohammed, I. Y., Damudi, H., Bello, B., Yahaya, S. I., Kurawa, M., Musa, S., & Ibrahim, Z. U. (2015). Biochemical Assessment of Pregnancy-Related Physiological Changes in Renal Function. American Scientific Research Journal for Engineering, Technology, and Sciences, 14(3), 264–271. Retrieved from https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/1214

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Vol. 14 No. 3 (2015): VOLUME 14, ISSUE 3: (DECEMBER - 2015)

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